Matrix Metalloproteinase Modulation in Cervical Cancer

Rocha NP, Lopes GS, Bonecini-Almeida MG and Fernandes ATG

Laboratory of Immunology and Immunogenetics in Infectious Diseases Evandro Chagas, Oswaldo Cruz Foundation, Brazil

^*Correspondance to: Ana Teresa Gomes Fernandes 

 PDF  Full Text Review Article | Open Access

Abstract:

Cervical Cancer (CC) is the fourth most common gynecological cancer and one of the most common causes of mortality in women in developing nations. HPV-related CC is a high spectrum disease with a gradual progression from pre-malignant condition to an aggressive disease. HPV cervical inflammatory process and subsequent pre-malignant lesions development are induced directly or indirectly by a complex system of interaction between oncogenes and host factors, secreted by keratinocytes, immune cells and Extracellular Matrix (ECM). ECM development and modeling can be regulated through the expression of Metalloproteinases (MMPs), which have been associated with several types of tumors, including CC. The present review summarizes how MMPs may be regulated in Tumor Microenvironment (TME) and discusses the role of HPV in modulating MMPs in cervical carcinogenesis.

Keywords:

Metalloproteinase; Cervical cancer; HPV; Modulation

Cite the Article:

Rocha NP, Lopes GS, Bonecini- Almeida MG, Fernandes ATG. Matrix Metalloproteinase Modulation in Cervical Cancer. Clin Oncol. 2024;9:2079..