Prostate-Specific Antigen Kinetics after Carbon-Ion Radiotherapy in Patients with Localized Prostate Cancer: Single Center Preliminary Experience in Japan

Suzuki O, Anzai M, Uchida H, Teshima T, Miyake H and Fujimoto J

Osaka Heavy Ion Therapy Center, Japan
Department of Urology, Hamamatsu University School of Medicine, Japan

^*Correspondance to: Osamu Suzuki 

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Abstract:

Currently, Carbon-Ion Radiation Therapy (CIRT) is regarded as one of the effective therapeutic options for patients with localized Prostate Cancer (PC); however, Prostate-Specific Antigen (PSA) kinetics following CIRT have not been well documented. This study included a total of 116 patients with low or intermediate-risk localized PC who underwent CIRT with a prescription dose
of 51.6 Gy in 12 fractions over 3 weeks, and characterized post-treatment changes in PSA values in these patients. PSA values 1 and 2 years after CIRT in these patients were reduced by 69 and 77%, respectively, relative to baseline values at diagnosis, and only 1 (0.86%) of the 116 was diagnosed with PSA failure. Collectively, these findings indicate that CIRT as monotherapy could efficaciously control PSA values in the majority patients with low or intermediate-risk localized PC.

Keywords:

Carbon-ion radiation therapy; Localized prostate cancer; PSA kinetics

Cite the Article:

Suzuki O, Anzai M, Uchida H, Teshima T, Miyake H, Fujimoto J. Prostate-Specific Antigen Kinetics after Carbon-Ion Radiotherapy in Patients with Localized Prostate Cancer: Single Center Preliminary Experience in Japan. Clin Oncol. 2023;8:1996..