Roles of Histone Modifications in Gastrointestinal Tumorigenesis

Jing Liu and Li Li

Department of Medicine and Stem Cell Research, Shanghai Jiao Tong University, Shanghai, China

^*Correspondance to: Li Li 

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Abstract:

Histone modifications play important roles in gastrointestinal tumorigenesis as tumor suppressors or oncogenic drivers depending on the type of tumor and histone modification. The diversity of histone modifications leads to a remarkable complexity in the functions and mechanisms they regulate, which are gradually beginning to be elucidated. This review concentrates on current research regarding the roles of histone modifications and associated histone-modifying enzymes in gastrointestinal tumorigenesis

Keywords:

Histone modification; Tumorigenesis; Epigenetics

Cite the Article:

Liu J, Li L. Roles of Histone Modifications in Gastrointestinal Tumorigenesis. Clin Oncol. 2020; 5: 1694.