Clin Oncol | Volume 6, Issue 1 | Case Report | Open Access

Isolated Kidney Metastases from Rectal Cancer: Report of an Unusual Pattern of Recurrence

Gerardo Rosati^1*, Francesco Conte², Patrizia Siciliano³, Marianna Giampaglia¹, Domenico Bilancia¹, and Enrico Scarano²

¹Medical Oncology Unit, San Carlo Hospital, Potenza, Italy
²Department of Radiology, San Carlo Hospital, Potenza, Italy
³Department of Histopathology, San Carlo Hospital, Potenza, Italy

^*Correspondance to: Gerardo Rosati 

Abstract

Kidney metastases from Rectal Cancer (RC) are quite rare. Only one case has, to the best of our knowledge, been reported. We present the case of a 56-year-old man with lung metastases from a rectal adenocarcinoma diagnosed in October 2015. In June 2018, he developed microhematuria during treatment with regorafenib administered as second-line therapy. The computed tomography scans of the whole body revealed lung disease progression and a solid mass in the cortical site of the left lower kidney. A biopsy was performed and the pathologic examination showed moderately differentiated adenocarcinoma consistent with RC. The tumoral cells stained positively for cytokeratine 20 and CDX2. The administration of third-line chemotherapy plus aflibercept resulted in a dimension reduction of metastases and disappearance of microhematuria. Here we describe the advantages of diagnosing this unusual pattern of metastasization from RC and how it can be explained.

Keywords:

Arterial dissemination; Chemotherapy; Kidney metastases; Rectal cancer; Regorafenib

Citation:

Rosati G, Conte F, Siciliano P, Giampaglia M, Bilancia D, Scarano E. Isolated Kidney Metastases from Rectal Cancer: Report of an Unusual Pattern of Recurrence. Clin Oncol. 2021;6:1858..