Gerardo Rosati1*, Francesco Conte2, Patrizia Siciliano3, Marianna Giampaglia1, Domenico Bilancia1, and Enrico Scarano2
1Medical Oncology Unit, San Carlo Hospital, Potenza, Italy
2Department of Radiology, San Carlo Hospital, Potenza, Italy
3Department of Histopathology, San Carlo Hospital, Potenza, Italy
Kidney metastases from Rectal Cancer (RC) are quite rare. Only one case has, to the best of our knowledge, been reported. We present the case of a 56-year-old man with lung metastases from a rectal adenocarcinoma diagnosed in October 2015. In June 2018, he developed microhematuria during treatment with regorafenib administered as second-line therapy. The computed tomography scans of the whole body revealed lung disease progression and a solid mass in the cortical site of the left lower kidney. A biopsy was performed and the pathologic examination showed moderately differentiated adenocarcinoma consistent with RC. The tumoral cells stained positively for cytokeratine 20 and CDX2. The administration of third-line chemotherapy plus aflibercept resulted in a dimension reduction of metastases and disappearance of microhematuria. Here we describe the advantages of diagnosing this unusual pattern of metastasization from RC and how it can be explained.
Arterial dissemination; Chemotherapy; Kidney metastases; Rectal cancer; Regorafenib
Rosati G, Conte F, Siciliano P, Giampaglia M, Bilancia D, Scarano E. Isolated Kidney Metastases from Rectal Cancer: Report of an Unusual Pattern of Recurrence. Clin Oncol. 2021;6:1858..