Identification of Ethylenediurea and Benzyl (Phenoxy) Acetic Acid Derivatives, a Potential Cocktail Therapy for Ischemia

Alexandre Bridoux, Dhruba J Bharali, Murat Yalcin and Shaker A Mousa

The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, USA Department of Physiology, Uludag University, Turkey French Association of Pharmaceutical Chemistry, France

^*Correspondance to: Alexandre Bridoux 

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Abstract:

The cell-membrane integrin αv β3 was shown to stimulate angiogenesis after binding the thyroid hormone and its analogue GC-1 (pM range). Ethylenediurea (EDU), a potent UV and ozone protector for plants, could show a potent antioxidant effect (low µM range) if modified as a catechol analogue. Probing the two potent low molecular weight drugs as a new combined treatment for limb ischemia has been addressed. As a first step toward this goal, the relative beneficial effect of each drug analog against models of angiogenesis and lipid peroxidation was assayed. The synthesized GC-1 derivatives QH-1- QH-8 (thyroid hormone-like compounds) and some catechol derivatives of EDU were tested in the Chick chorioallantoic membrane assay and the lipid peroxidation assay. The bioactivities of both classes of molecules are complimentary. Our results show that a GC-1 analogue and an EDU analogue could therefore be tested as candidates in preclinical studies as a pro-angiogenesis agent and its therapeutic adjuvant, respectively

Keywords:

Ischemia; GC-1; Thyroid hormone analogs; Ethylenediurea; Antioxidant

Cite the Article:

Bridoux A, Bharali DJ, Yalcin M, Mousa SA. Identification of Ethylenediurea and Benzyl (Phenoxy) Acetic Acid Derivatives, a Potential Cocktail Therapy for Ischemia. Clin Oncol. 2019;4:1662.