Clinicopathological Features and Prognosis in Patients with Cholangiolocellular Carcinoma and Hepatocellular Carcinoma

Min Deng, Lin Fang, Xian-Chao Guo, Kit-Sum Tsui and Rong-Ping Guo

Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, China
State Key Laboratory of Oncology in South China, China
Collaborative Innovation Center for Cancer Medicine, China
Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, China
Department of Surgery, Shenzhen Hospital, University of Chinese Academy of Sciences, China
Department of Surgery, University of Hong Kong, Hong Kong
These authors contributed equally to the work

^*Correspondance to: Rong-Ping Guo 

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Abstract:

Cholangiolocellular Carcinoma (CLC) is a subtype of intrahepatic Cholangiocarcinoma (ICC). The study aimed to examine CLC and Hepatocellular Carcinoma (HCC) and to provide reliable proof for selecting reasonable diagnosis and treatment for CLC patients. The characteristics of two liver malignancies were analyzed from the clinicopathological features and survival outcomes.
Our research revealed that number of patients with Elevated Alpha-Fetoprotein (AFP) (p=0.0002), Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV) infection (p<0.0001), single tumor (p=0.0075), and liver fibrosis or cirrhosis (p=0.0043) were significantly lower in the CLC group than in the HCC group. The tumor size in the CLC group was significantly larger than that of the HCC group (p=0.02). The proportion of poorly or undifferentiated tumors (p=0.0003) and the number of neural invasions (p<0.0001) were significantly higher in the CLC group than in the HCC group (p=0.0003). In addition, the overall median survival rate (p=0.0032) and the disease-free survival rate were significantly lower in CLC patients than in HCC patients (p=0.0015). Furthermore multivariate analysis revealed the types and the differentiation of tumor and neural invasion can be regarded as significant independent prognostic factors for CLC and HCC patients’ overall survival. In conclusion, CLC has the dual clinicopathological features of HCC and conventional Intrahepatic Cholangiocarcinoma (cICC). The prognosis of CLC was poorer than that of HCC. It is necessary to further explore the intrinsic pathological mechanism of CLC and develop targeted diagnosis and treatment strategies for it.

Keywords:

Liver; Malignancy; Clinical; Pathological; Prognosis

Cite the Article:

Deng M, Fang L, Guo X-C, Tsui K-S, Guo R-P. Clinicopathological Features and Prognosis in Patients with Cholangiolocellular Carcinoma and Hepatocellular Carcinoma. Clin Oncol. 2021;6:1795..