Analysis of the Network Pharmacological Mechanism of Action of Panax Ginseng Component-Target-Pathway on Diabetic Eye Disease

Ye Liao, Huanyu Che, Xuekun Liu, Xin Guo and Tianpu Feng

The Charles Perkins Centre, The University of Sydney, Australia School of Pharmacy and Medicine, Tonghua Normal University, China Department of Pharmacy, Jinzhou Medical University, China

^*Correspondance to: Ye Liao 

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Abstract:

The key targets and pathways of Panax notoginseng in treating diabetic eye disease were explored based on network pharmacology and molecular informatics methods. The chemical composition of Panax notoginseng was obtained by TCMSP database, the potential target of Panax notoginseng was predicted by Swiss Target Prediction database, the diabetic eye disease target was queried by Gene Cards database, and the intersection of Panax notoginseng component target and eye disease target was visualized by Winn Diagram. The protein-protein interaction network was constructed using STRING database, and topological parameter analysis was carried out on Cytoscape to obtain the key targets of Panax notoginseng in the treatment of eye disease. GO and KEGG analysis were carried out based on Metascape database, and GO enrichment heat map and KEGG enrichment bubble map of core targets were constructed using Weisengxin website. Eight effective chemical components of Panax notoginseng were screened out, including 147 key targets, and 1366 key targets of diabetic eye disease. Seventy-seven overlapping targets were screened out by intersection analysis. The enrichment analysis of intersection targets showed that Panax notoginseng had effects on diabetic eye disease through 16 KEGG and 58 Go-related signaling pathways. This study shows how eight active chemical components of Panax notoginseng play a role in the treatment of diabetic eye disease through nine key targets.

Keywords:

Network pharmacology; Molecular informatics; Notoginseng; Diabetic eye disease

Cite the Article:

Liao Y, Che H, Liu X, Guo X, Feng T. Analysis of the Network Pharmacological Mechanism of Action of Panax Ginseng Component-Target-Pathway on Diabetic Eye Disease. Clin Oncol. 2025; 10: 2121..