The Clinical Outcomes of Brain Metastasis from Colorectal Cancer: A Single Center Retrospective Study

Eun Mi Lee

Department of Internal Medicine, Kosin University College of Medicine

^*Correspondance to: Eun Mi Lee 

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Abstract:

Background: Brain metastasis from Colorectal Cancer (CRC) is an uncommon and late event of disease course. The prognosis becomes poor once brain metastasis occurs. This study aimed to investigate the clinical characteristics and outcomes of patients with CRC diagnosed with brain metastasis. Methods: This study retrospectively analyzed the clinical data of patients with brain metastasis from CRC at Kosin University of Gospel Hospital from January 2018 to December 2023. Results: This study enrolled 27 patients. The median age of patients at the time of brain metastasis diagnosis was 63 years (range, 50-80), and 37.0 % of patients demonstrated the Eastern Cooperative Oncology Group (EGOG) Performance Status (PS) (0 or 1). All patients exhibited extra cranial metastasis, and the lung was the most prevalent metastatic site (92.6%). A total of 24 patients (88.9%) received local treatment for brain metastasis and subsequent chemotherapy was administered in 12 patients. The median survival after brain metastasis diagnosis was 3.8 months (95% Confidence Interval [CI]; 3.0-4.8), and that after initial CRC diagnosis was 53.3 months (95% CI; 39.0–67.6). The multivariate analysis of prognostic analysis revealed that ECOG PS, liver metastasis, and chemotherapy after brain metastasis diagnosis were associated with survival. Conclusion: This study revealed that brain metastasis form CRC developed in the late stage of the disease, and the prognosis brain metastasis diagnosis was dismal.

Keywords:

Brain metastasis; Intra cranial tumor; Colorectal cancer; Chemotherapy

Cite the Article:

Eun Mi Lee. The Clinical Outcomes of Brain Metastasis from Colorectal Cancer: A Single Center Retrospective Study. Clin Oncol. 2024;9:2113..