Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Radiation Therapy
  •  Lymphoma
  •  Haemato-Oncology
  •  Adjuvant Therapy
  •  Chemotherapy and Radiotherapy
  •  Radiological Techniques and Scans
  •  Radiation Oncology
  •  Head and Neck Oncology


Citation: Clin Oncol. 2021;6(1):1801.DOI: 10.25107/2474-1663.1801

Percutaneous Cryoablation for Clinical Stage I Non-Small Cell Lung Cancer: Histology, Results, and Safety

Frank A Baciewicz Jr, Hakob Kocharyan, Deborah Hackstock, Lance Heilbrun, Hussein D Aoun, Fulvio Lonardo and Peter J Littrup

Department of Cardiothoracic Surgery, Wayne State University, USA
Karmanos Cancer Institute, USA
Department of Radiology, Detroit Medical Center/Wayne State University, USA
Department of Radiology, Karmanos Cancer Institute/Wayne State University, USA
Department of Pathology, Wayne State University, USA
Department of Diagnostic Imaging, Ascension Medical Center, Rochester, USA

*Correspondance to: Frank A Baciewicz Jr 

 PDF  Full Text Research Article | Open Access


Objectives: Lobectomy for clinical stage I lung cancer has an 80% to 90% 5-year survival rate but has morbidity and mortality risks. Not all clinical stage I patients are surgical candidates and some refuse surgery. This study’s primary endpoint was to describe the histologic outcome of stage I lung cancer patients treated by percutaneous CT guided cryoablation (PCA).
Methods: Histologically confirmed, clinically staged stage I tumors underwent PCA with standard cryo probes (Endocare, Irvine, Cal). Intraprocedure CT documentation of visible ice (-0 degree Celsius) extending beyond the tumor margins (~1 cm) was performed. Resection of the ablation zone/tumor and lymph node dissection with extensive histologic review was then performed.
Results: Nine patients (7 male, 2 female), median age 65.9 years (range 52 to 78) with mean CT scan tumor diameter 1.7 cm ± 0.3 cm underwent PCA for 4 right upper lobe, 4 left upper lobe and 1 right lower lobe tumors. There were 2 grade 3 CTCAE and 3 grade 1-2 CTCAE complications. Two patients required admission after PCA. Surgical resection via thoracotomy was performed a median of 64.6 days after PCA. Two resections showed only 1 microscopic focus of tumor (≤ 1 mm). Only one showed macroscopic residual tumor (1 cm) and the remaining 6 showed no tumor. The only patient with macroscopic residual disease had pathologic stage IIIB.
Conclusion: Outpatient PCA in clinical stage I Non-Small Cell Lung Cancer (NSCLC) offers a safe, feasible treatment with complete local tumor eradiation in 6/9 patients.


Cite the Article:

Baciewicz FA Jr, Kocharyan H, Hackstock D, Heilbrun L, Aoun HD, Lonardo F, et al. Percutaneous Cryoablation for Clinical Stage I Non-Small Cell Lung Cancer: Histology, Results, and Safety. Clin Oncol. 2021;6:1801..

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