Tumor Size and Nodal Status of Invasive Breast Carcinomas in Women with Dense Breasts Depending on Previous Breast MRI

Uwe Fischer

Diagnostic Breast Center Göttingen

^*Correspondance to: Uwe Fischer 

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Abstract:

Purpose: The study evaluates the influence of prior breast MRI on the size of invasive breast carcinomas and their nodal status at the time of diagnosis in women with density type ACR C and D. Material and Methods: The evaluation included 444 patients with histologically verified invasive breast cancer after percutaneous or open biopsy to clear findings categorized as MR-BIRADS 4 or 5. All patients had high tissue density type ACR C or D. The study differentiated two groups: Patients, who had a breast MRI with unsuspicious result in the last 5 years (group A), and patients who had no MRI of the breast before (group B). Moreover, the significance of the time interval between previous MRI and MRI was also evaluated. Results: In the period from 2014 to 2020, 15,673 breast MRIs were performed during breast consultations for different indications. 2,170 findings were categorized as MR-BIRADS 4 or 5. At least, 444 cases with invasive breast cancer (319 NOS, 94 ILC, 18 TUB, 8 MUC, 5 other) were included in the analysis after elimination of cases with exclusion criteria. Patient in group A (n=113) had an average tumor size of 11.1 mm at the time of diagnosis, compared to patients in group B (n=331) with 21.9 mm. Regarding only women in a screening constellation (n=145), the average tumor size was 9.8 mm (previous MRT within last 2 years), 10.2 mm (previous MRI last 2-3 years), and 15.6 mm without previous MRI. The average tumor size was also higher for all other indications: Unclear cutaneous or palpable findings (19.0 mm; n=16 vs. 24.0 mm; n=82), unclear mammography (17.5 mm; n=21) or ultrasound findings (18.4 mm; n=39), CUP syndrome (11.0 mm; n=3) and local MR staging with BIRADS 5 or 6 (24.3 mm; n=138). The rate of nodal-positive carcinomas was 6.2% (7/113) with previous MRI and 28.4% (94/331) without MRI within the last 5 years. Conclusion: If women with density type ACR C and D, who had a previous normal breast MRI within the last 5 years, get an invasive breast cancer, the tumor size will be around half of the size compared to women without previous MRI. The rate of nodal-positive carcinomas in invasive breast cancer is reduced by 75% with previous MRI.

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Cite the Article:

Uwe Fischer. Tumor Size and Nodal Status of Invasive Breast Carcinomas in Women with Dense Breasts Depending on Previous Breast MRI. Clin Oncol. 2024;9:2104..