Pan-Cancer Analysis Reveals the Prognostic Value and the Immune Response of Galanin

Deng X, He P, Huang H, Yang X, Gan Z and Yang J

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, China
Department of Cardiology, Shenzhen People’s’ Hospital, Jinan University, China
These authors contributed equally to this work

^*Correspondance to: Jun Yang 

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Abstract:

Lung cancer is one of the most common cancers with high cancer-related mortality worldwide. Increasing evidence revealed that Galanin (GAL) and galanin receptors become biomarker in several endocrine tumors. In this study, we first performed pan-cancer analysis for GAL’s expression and prognosis using The Cancer Genome Atlas (TCGA) and found that GAL might be a potential oncogene in lung cancer and endometrial cancer. We performed bioinformatics analysis on lung cancer from TCGA, and jointly analyzed with online databases such as LinkedOmics, TIMER and TISIDB. We found that lower expression of GAL was accompanied with worse outcomes of patients with lung cancer. Moreover, GAL expression was significantly correlated with a variety of the Tumor-Infiltrating Immune Cells (TIICs). GAL level was significantly positively associated with tumor immune cell infiltration, biomarkers of immune cells and immune checkpoint expression in lung cancer. Collectively, our findings elucidated that GAL correlated with poor prognosis and tumor immune infiltration in lung cancer.

Keywords:

TCGA; Galanin; NSCLC; Immune infiltration; Prognosis

Cite the Article:

Deng X, He P, Huang H, Yang X, Gan Z, Yang J. Pan-Cancer Analysis Reveals the Prognostic Value and the Immune Response of Galanin. Clin Oncol. 2023;8:2017..