Palbociclib Efficacy and Safety in Metastatic Breast Cancer with Spinal Cord Compression

Valentina Rossi, Giuseppe Schettini, Natale Russo, Lucia Rosalba Grillo, Renato Gigli, Fabio Di Cesare, Fabrizia Scardamaglia, Francesca Svegliati, Antonella Muzzi, Daniela Giammarino and Leonardo Vigna

Department of Breast Oncology, San Camillo Forlanini Hospital, Italy Department of Neurosurgery, San Camillo Forlanini Hospital, Italy Department of Pathology, San Camillo Forlanini Hospital, Italy Department of Neuroradiology, San Camillo Forlanini Hospital, Italy Department of Breast Surgery, San Camillo Forlanini Hospital, Italy Department of Breast Radiology, San Camillo Forlanini Hospital, Italy Department of Gynecology, San Camillo Forlanini Hospital, Italy Department of Radiotherapy, San Camillo Forlanini Hospital, Italy

^*Correspondance to: Valentina Rossi 

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Abstract:

Symptomatic Metastatic Spinal Cord Compression (MSCC) in Breast Cancer (BC) is clinically rare. MSCC represents an oncological emergency, thus necessitating prompt diagnosis and early treatment for local and systemic disease control. Palbociclib, a potent cyclin-dependent kinase 4/6 inhibitor, has been recently approved in combination with Endocrine Therapy (ET) for treatment of hormone-receptor-positive, human epidermal growth factor receptor-negative metastatic BC. There is currently no evidence supporting palbociclib use in MSCC-BC. We report a 36-year-old pregnant woman presenting with a twomonth history of middle thoracic back pain and one-week of leg weakness due to MSCC-BC. A prompt diagnosis led to an early caesarean section, followed by neurosurgical decompression plus radiotherapy for local tumor control. Subsequently, further local and systemic tumor control was attained with palbociclib plus ET, without any unexpected side effects. To the best of our knowledge, this is the first case demonstrating the efficacy and safety of palbociclib in MSCC-BC.

Keywords:

Palbociclib; Spinal cord compression; Metastatic breast cancer; Endocrine therapy

Cite the Article:

Rossi V, Schettini G, Russo N, Rosalba Grillo L, Gigli R, Di Cesare F, et al. Palbociclib Efficacy and Safety in Metastatic Breast Cancer with Spinal Cord Compression. Clin Oncol. 2020; 5: 1732.