Successful Allogeneic Hematopoietic Stem Cells Transplantation with Treosulfan-based Conditioning Despite Advanced Heart Insufficiency

Miroslaw Markiewicz, Malgorzata Kopera, Monika Dzierzak-Mietla and Krzysztof Bialas

Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Poland

^*Correspondance to: Miroslaw Markiewicz 

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Abstract:

We report a case of a 47-year old patient with intermediate risk Acute Myeloblastic Leukemia (AML) in first remission with positive minimal residual disease and heart insufficiency due to dilated cardiomyopathy with low (35% to 38%) Left Ventricular Ejection Fraction (LVEF), who was treated with allogeneic Hematopoietic Stem Cells Transplantation (HSCT) from HLA-matched sibling-donor following treosulfan-based myeloablative conditioning. Heart function did not worsen following conditioning and transplantation. Patient is alive over 8 years post-transplant, with stable full donor’s chimerism, no evidence of GVHD and slightly improved heart function. Our report proves that HSCT can be successfully performed in patients with low LVEF.

Keywords:

Allogeneic; Hematopoietic stem cells transplantation; Heart insufficiency; Left ventricular ejection fraction; Treosulfan

Cite the Article:

Markiewicz M, Kopera M, DzierzakMietla M, Bialas K. Successful Allogeneic Hematopoietic Stem Cells Transplantation with Treosulfan-based Conditioning Despite Advanced Heart Insufficiency. Clin Oncol. 2018; 3: 1509.