Introduction to 5-Aminolevulinic Acid-Protoporphyrin IXMediated Radiodynamic Therapy (RDT)

Junko Takahashi and Hitoshi Iwahashi

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan

^*Correspondance to: Junko Takahashi 

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Abstract:

Photodynamic Therapy (PDT) is a light-based method that uses photo-reactive molecules, such as protoporphyrin IX (PpIX), to ablate tumors. Recently, PpIX was shown to act as a radio-reactive molecule by enhancing generation of Reactive Oxygen Species (ROS) upon X-ray irradiation. This characteristic enables radiodynamic Therapy (RDT), which uses radiation as a physical stimulus instead of light used in photodynamic therapy. The merit of RDT over PDT is the X-ray’s penetrability through tissues, which will find many applications for treatment of deep cancers. In this mini-review, we discuss the potential applications of radiodynamic therapy.

Keywords:

Radiotherapy; Radiodynamic therapy (RDT); 5-aminolevulinic acid (5-ALA); Protoporphyrin IX (PpIX); Photodynamic therapy (PDT)

Cite the Article:

Takahashi J, Iwahashi H. Introduction to 5-Aminolevulinic Acid-Protoporphyrin IX-Mediated Radiodynamic Therapy (RDT). Clin Oncol. 2017; 2: 1330.