Outcomes of Surgery in Elderly Patients with a Retroperitoneal Soft Tissue Sarcoma

Macovei R, Sourouille I, Levy A, Mir O, Ceribelli C, Terrier P, LePéchoux C, LeCesne A and Honoré C

Department of Surgical Oncology, Gustave Roussy Cancer Campus, France
Department of Radiotherapy, Gustave Roussy Cancer Campus, France
Department of Pathology, Gustave Roussy Cancer Campus, France
Department of Medical Oncology, Gustave Roussy Cancer Campus, France

^*Correspondance to: Honor� C 

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Abstract:

Aim of this Study: To evaluate short and long term results after curative surgery for a retroperitoneal sarcoma (RPS) in elderly patients.
Methods: We retrospectively analyzed data of all patients operated in our single tertiary care center for a non-metastatic RPS and identified patients older than 70.
Results: Among 304 patients with a RPS treated between 1994 and 2015, 62 (20%) were older than 70 (median age 75 years, range: 70-85). The median tumor size was 26 cm (range: 11-46). 46 patients (74%) had mass-related symptoms at the time of diagnosis. The most frequent histological subtype was liposarcoma (76%). 22 patients (35%) had a perioperative radiotherapy and/or chemotherapy. 58 patients (94%) had macroscopically complete resection. The postoperative mortality was 6% and severe morbidity (including deceased patients) was 39%. A reoperation was required for 11 patients (18%). After a median follow-up of 20 months (range: 0-120), the 5-year Overall Survival (OS) rate was 90% (IC95%: 79%-100%) and the median OS was not reached. Cancer specific death rate was 86%. No prognostic factor for disease specific survival was detected. The 5-years disease free survival DFS rate was 52% (IC 95%: 33%-84%) and the 5-years loco-regional recurrence-free survival (LRRFS) rate was 52% (IC 95%: 33%-84%). Median DFS was 94 months (range: 35-139). Reoperation after inappropriate surgery and postoperative morbidity were independent predictive factors of loco-regional relapse. No predictive factors of distant metastasis were found. Conclusions: Curative surgery is feasible in selected elderly patients with an acceptable morbidity and with potential action on symptoms. It enables a prolonged survival. Future studies should focus on selection process.

Keywords:

Soft tissue sarcoma; Surgery; Elderly; Cancer; Retroperitoneal sarcoma

Cite the Article:

Macovei R, Sourouille I, Levy A, Mir O, Ceribelli C, Terrier P, et al. Outcomes of Surgery in Elderly Patients with a Retroperitoneal Soft Tissue Sarcoma. Clin Oncol. 2016; 1: 1102.