Distinguishing Malignant from Benign Prostate Tumors using Br, Fe, Rb, Sr, and Zn Content in Prostatic Tissue

Rossmann M, Zaichick S and Zaichick V

Department of Biochemistry, University of Cambridge, UK
Department of Medicine, University of Illinois College of Medicine, USA
Department of Radionuclide Diagnostics Medical Radiological Research Centre, Russia

^*Correspondance to: Zaichick V 

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Abstract:

Contents of Br, Fe, Rb, Sr, and Zn in normal (n=37), benign hypertrophic (n=43) and cancerous tissues (n=60) of the human prostate gland were investigated by radionuclide-induced (109Cd) energy dispersive X-ray fluorescent (EDXRF). Mean values (M±SΕΜ) for mass fraction (mg/kg on dry mass basis) of trace element in the normal tissue were as follows: Br 40.6±5.6, Fe 118±8, Rb 16.3±1.1, Sr 2.5±0.4, and Zn 1154±119, respectively. Mean values (M±SΕΜ) for ratio of mass fractions were: Zn/Br 39.1±6.2, Zn/Fe 11.2±1.3, Zn/Rb 71.7±9.0, and Zn/Sr 534±83, respectively. It was observed that in benign hypertrophic tissues the levels of Br, Fe, Rb, Sr, and Zn were equal to those in normal prostate tissues. By contrast, the levels of Rb and Zn were significantly lower and those of Br and Sr were significantly higher in cancerous tissues than in normal tissues. The Zn mass fraction, as well as Zn/Br and Zn/Sr ratios, were the most informative indicators for distinguishing malignant from benign prostate with sensitivity, specificity, and accuracy in the ranges 95-100%, 92-98%, and 95-98%, respectively. Obtained data allowed us to adequately evaluate the importance of trace element content and their ratios for the diagnosis of prostate cancer.

Keywords:

Trace elements; Intact prostate; Benign prostatic hyperplasia; Prostate cancer; Energy-dispersive X-ray fluorescent analysis

Cite the Article:

Rossmann M, Zaichick S, Zaichick V. Distinguishing Malignant from Benign Prostate Tumors using Br, Fe, Rb, Sr, and Zn Content in Prostatic Tissue. Clin Oncol. 2016; 1: 1054.