Postoperative 5-Year Survival and Related Risk Factors of Colon Cancer Patients Undergoing Propofol vs. Sevoflurane
Anesthesia: A Retrospective Cohort Study

Jian Xu, Zhenglian Gao, Mark Coburn, Daqing Ma and Kun Wang

Department of Anesthesiology, Harbin Medical University Cancer Hospital, China
Department of Anesthesiology, Canzhou Central Hospital, China
Department of Anesthesiology, Panzhihua Central Hospital, China
Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Germany
Department of Surgery and Cancer, Chelsea and Westminster Hospital, UK
Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, China

^*Correspondance to: Kun Wang 

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Abstract:

Purpose: Anesthetic agents affect the biological behavior of tumor cells and long-term oncologic outcomes. We investigated the association of anesthetics and 5-year survival of colon cancer patients.
Methods: The data from patients underwent colon cancer surgery from July 01^st, 2009 to July 31^st, 2014 were analyzed. Patients were grouped according propofol or sevoflurane used during surgery. Five-year survivals were analyzed with Kaplan-Meier method, and Cox regression models were used to identify risk factors of death.
Results: Of 1,289 colon cancer patients, 913 patients with propofol anesthesia and 376 with sevoflurane anesthesia were eligible for analysis. After propensity score matching, 375 patients remained in each group, and 5-year overall survival was 79.7% (95% Confidence Interval [CI], 0.76-0.84) in the propofol group, and 78.1% (95% CI, 0.74-0.82) in the sevoflurane group, and 5-year
recurrence-free survival was 73.4% (95% CI, 0.69-0.78) and 70.4% (95% CI, 0.66-0.75), respectively. Type of anesthetic did not affect 5-year overall survival and recurrence-free survival with the logrank test (P=0.513, 0.293, respectively). Related risk factors were age, anesthesia duration, open surgery, CEA and CA199 values, vascular or nerve infiltration, TNM, and adjuvant therapy.
Conclusion: There were no benefits in 5-year survival in propofol anesthesia vs. sevoflurane anesthesia after colon cancer surgery.

Keywords:

Propofol; Sevoflurane; Colon cancer; Surgery; Survival; Risk factors

Cite the Article:

Xu J, Gao Z, Coburn M, Ma D, Wang K. Postoperative 5-Year Survival and Related Risk Factors of Colon Cancer Patients Undergoing Propofol vs. Sevoflurane Anesthesia: A Retrospective Cohort Study. Clin Oncol. 2022;7:1933..