Meenakshi Ponnana1 and Sumanlatha Gaddam1,2*
1Bhagwan Mahavir Medical Research Center, India
2Deparment of Genetics, Osmania University, India
Purpose: The association between Pulmonary Tuberculosis (PTB) and Diabetes Mellitus (DM) has attracted much attention. They coincide with micronutrient deficiencies among which Vitamin D plays a major role. Our aim was to investigate serum 25 [OH] Vitamin D levels in DM patients with TB (TBDM).
Methods: Total of 249 subjects were studied including TBDM patients, PTB patients, DM patients and Healthy Controls (HC).
Results: There was a significant difference in age of the TBDM patients (p<0.001), PTB females (p<0.03) and DM males (p<0.001) when compared to HC. BMI was found to be significantly low in TBDM males (p<0.007), females (p<0.026) and PTB patients (p<0.0001). TBDM & DM patients with high blood sugar levels & DM duration with <5 years was associated with insufficient vitamin D levels. Vitamin D levels were found to be low in TBDM & DM (p<0.005) patients and in PTB patients (p<0.0005). DM patients with insufficient vitamin D levels have shown significance at p<0.03.
Conclusion: Severe hypovitaminosis D is more in DM patients with high blood sugar levels raising the risk of TB. Vitamin D may thus be considered as the missing link between emerging epidemic of PTB and DM.
Tuberculosis; Diabetes mellitus; Vitamin D levels; Blood sugar levels
Ponnana M, Gaddam S. Serum Vitamin D Levels in Diabetes Mellitus Patients with Pulmonary Tuberculosis. Clin Oncol. 2020;5:1716..