Clinical Factors Affecting Patients with Advanced Gastrointestinal Cancer with Weak Physical Status Receiving Low-Dose Chemotherapy and the Establishment of Risk Prediction Scoring System

Su Z, Zhang X, Cheng L, Gan H, Li Z, Wang Z and Li F

Department of Medical Oncology, Zhongshan Hospital (Xiamen), Fudan University, China
Department of Xiamen Clinical Research Center for Cancer Therapy, Xiamen, China
Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
These authors contributed equally to this work

^*Correspondance to: Fang Li 

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Abstract:

Introduction: To explore the risk factors affecting patients with advanced gastrointestinal cancer in weak physical status receiving low-dose chemotherapy and establish a prediction scoring system for the risks.
Methods: 141 patients with advanced gastrointestinal tumors who received low-dose chemotherapy from July 2018 to March 2021 were enrolled to analyze the clinical factors that may affect the prognosis.
Results: Univariate analysis revealed that body mass index, physical status score, pain, type of primary tumor, number of metastatic sites, symptom based qualitative evaluation of gastrointestinal function, CT image-based intestinal dilatation, ascites, hemoglobin, albumin, C-reactive protein, prothrombin time, D-dimer were all factors associating the prognosis of patients (all P<0.05); multivariate analysis revealed that pain; the type of primary tumor was gastric cancer; the qualitative evaluation of gastrointestinal function based on symptoms was gastrointestinal dysfunction, ascites positive and elevated C-reactive protein were the five independent risk factors affecting the prognosis. The prognostic risk prediction scoring system was established according to the results of multivariate regression analysis. Patients with pain, gastric cancer, gastrointestinal dysfunction,
ascites positive and elevated C-reactive protein were scored 1 point respectively. In higher scores group, the median survival time of patients was shorter.
Conclusion: Pain, gastric cancer, gastrointestinal dysfunction, ascites positive and elevated C-reactive protein were independent risk factors for the prognosis of patients with advanced gastrointestinal cancer in weak physical status receiving low-dose chemotherapy. The prognostic risk prediction scoring system combined with the above indicators may effectively predict the lowdose chemotherapy benefit population.

Keywords:

Gastrointestinal cancer; Weak physical status; Low-dose chemotherapy; Risk prediction scoring system

Cite the Article:

Su Z, Zhang X, Cheng L, Gan H, Li Z, Wang Z, et al. Clinical Factors Affecting Patients with Advanced Gastrointestinal Cancer with Weak Physical Status Receiving Low-Dose Chemotherapy and the Establishment of Risk Prediction Scoring System. Clin Oncol. 2023;8:1983..