Short Communication

Cerebral Localisation of a Gastric Malt Lymphoma with Partial Response after Chemotherapy

Sabbah Meriam1*, Bibani Norsaf1, Trad Dorra1, Ouakaa Asma1, Jouini Raja2, Ben Brahim Ehsen2, Elloumi Héla1 and Gargouri Dalila1
1Departement of Gastroenterology, Habib Thameur Hospital, Tunisia
2Departement of Pathology, Habib Thameur Hospital, Tunisia


*Corresponding author: Sabbah Meriam, Department of Gastroenterology, Habib Thameur Hospital, Tunis, Tunisia

Published: 18 Aug, 2018
Cite this article as: Meriam S, Norsaf B, Dorra T, Asma O, Raja J, Ehsen BB, et al. Cerebral Localisation of a Gastric Malt Lymphoma with Partial Response after Chemotherapy. Clin Oncol. 2018; 3: 1508.

Clinical Image

A 37 years old woman presented upper gastrointestinal bleeding. Upper endoscopy and biopsy confirmed a gastric MALT lymphoma (Figure 1). She also presented headache without localization signs at neurological examination. Cerebral MRI showed an expanding tissue tumor process of the left choroid plexus associated with peri-lesional edema (Figure 2). The biopsy could not be realized because high risk of bleeding due to the localization of the tumor. Lymphoma was classified stage IV E according to modified Ann Arbor Classification. She received Chemotherapy (CHOP protocol). Endoscopic control showed a regression of the lymphoma with histopathological remission according to GELA score. Headache improved after treatment and control MRI (Figure 3) showed partial regression of the tumor after systemic treatment (after 3 months).


Figure 1

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Figure 1
Initial histopathological examination : diffuse and abundant lymphoid infiltrate, realizing lymphoepithelial lesions: (Hematoxylin eosin x200) and CD20 expression of tumor cells with immunohistochemistry (G x200).

Figure 2

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Figure 2
Initial MRI showing an expanding tissue tumor process of the left choroid plexus associated with a signal anomaly opposite: peri-lesional edema (arrow).

Figure 3

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Figure 3
Control Computed tomography showing partial regression of the cerebral lesion (arrow).