Abstract || Clinics In Oncology™

Major Scope

Lung Cancer
Colorectal Cancer
Pancreatic Cancer
Breast Cancer
Prostate Cancer
Liver Cancer
Leukemia
Bladder Cancer
Kidney Cancer
Endometrial Cancer
Oncology Case Reports
Radiation Therapy

Abstract

Citation: Clin Oncol. 2026;11(1):2135.DOI: 10.25107/2474-1663-v11-id2135

Psychosocial Predictors of Health-Related Quality of Life in Lymphoma: A Multiple Mediation Model

Di Francesco G, Mezzapesa M , Cieri F , Bovero A , Pennese E and Di Ianni M

Hematology Section, Department of Oncology and Hematology, Pescara Hospital, Italy

Department of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, USA

Department of Neuroscience, Clinical Psychology Unit, University of Turin, Italy

Department of Medicine and Aging Sciences, University of Chieti-Pescara, Italy

^*Correspondance to: Di Francesco G

PDF Full Text Review Article | Open Access

Abstract:

Objective: To identify predictors of poorer Health-Related Quality of Life (HRQoL) in lymphoma, focusing on socio-demographic, clinical, and psychosocial variables.

Methods: One hundred twenty-six patients with Hodgkin lymphoma or non-Hodgkin lymphoma completed the EORTC QLQ-C30, Hospital Anxiety and Depression Scale, and Multidimensional Scale of Perceived Social Support.

Results: Depressive symptoms were significantly associated with poorer HRQoL (β = -0.54, p<0.001). Perceived social support was associated with lower depression and anxiety (β = -0.34, p<0.001; β = -0.19, p<0.01, respectively). Mediation analysis indicated that social support was indirectly associated with HRQoL, through depressive symptoms (β = 0.30, p<0.001).

Conclusion: Depressive symptoms showed a significant association with poorer HRQoL in lymphoma. Perceived Social support was associated with better HRQoL through its association with lower depressive symptoms. Identifying individuals at risk can inform targeted, timely psychosocial interventions to reduce distress and improve overall well-being. Findings support routine screening and monitoring in hematology care.

Keywords:

Quality of life; Lymphoma; Social support; Mediation model; Depression symptoms

Cite the Article:

Di Francesco G, Mezzapesa M, Cieri F, Bovero A, Pennese E, Di Ianni M.Psychosocial Predictors of HealthRelated Quality of Life in Lymphoma: A Multiple Mediation Model. Clin Oncol. 2026; 11: 2135.