A Case Report: Pancreatic Schwannoma, A Rare Benign Mimicker of Cystic Neoplasm of the Pancreas

Bhimsi Kandoriya, Hirdaya Hulas Nag, Pritesh Kumar N and Surbhi Goyal

Department of Surgical Gastroenterology, GB Pant Institute of Postgraduate Medical Education and Research, Delhi University, India Department of Pathology, GB Pant Institute of Postgraduate Medical Education and Research, Delhi University, India

^*Correspondance to: Hirdaya Hulas Nag 

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Abstract:

Background: Schwann cell tumours of the pancreas also known as Pancreatic Schwannoma (PS) is a very uncommon benign pancreatic space occupying lesion. Fewer than 80 cases of PS have been published in the English medical literature over the past forty years. Case Presentation: A 53-year-old female with hypertension and hypothyroidism presented with a five-year history of dull, non-colicky upper abdominal pain radiating to the back. Abdominal examination was unremarkable. The ultrasound and Computerized Tomography (CT) imaging revealed a 48 mm × 35 mm well-defined, multiloculated cystic lesion involving the pancreatic head. The tumor markers (CA 19-9 and CEA) tested within the expected reference range. Magnetic Resonance (MR) imaging and Endoscopic Ultrasound (EUS) confirmed the cystic nature of the lesion without mural nodules and no vascular involvement or ductal communication. EUS-guided Fine Needle Aspiration Cytology (FNAC) showed the mesenchymal cells of Schwannian origin. The patient underwent open enucleation, with intraoperative frozen section analysis revealed the benign mesenchymal pathology. Postoperative recovery was uneventful, and the patient was discharged on postoperative day six. Postoperative histopathology report confirmed the diagnosis of schwannoma. Conclusion: Pancreatic schwannomas are exceedingly uncommon benign lesions that deserves an inclusion in the differential diagnosis of the cystic pancreatic space occupying lesions. Diagnosis before surgery is challenging, but preoperative EUS-guided FNAC/Biopsy helps in diagnosis. Treatment of the pancreatic schwannomas requires enucleation or pancreatic resection, both associated with a good prognosis and no reported recurrences.

Keywords:

Pancreatic schwannoma; Enucleation; Pancreatic resection; EUS; FNAC; Biopsy

Cite the Article:

Kandoriya B, Hulas Nag H, Srivastava A, Goyal S, Pritesh Kumar N. A Case Report: Pancreatic Schwannoma, A rare Benign mimicker of Cystic Neoplasm of the Pancreas. Clin Oncol. 2025; 10: 2126. ORCID ID: https:// orchid.org/0009-0006-7072-8015.