Prevalence of Thrombophilia in Lebanese Women with Recurrent Miscarriages

Fady El Karak, Elissa Chebly, Nahed Damaj, Andre Adaime, Nadine El Kassis, Georges Abi Tayeh, David Atallah and Assaad Keserwani

Department of Hematology-Oncology, Hôtel Dieu de France University Hospital, Faculty of Medicine-Saint Joseph University of Beirut, Beirut, Lebanon Department of Microbiology, Hôtel Dieu de France University Hospital, Faculty of Medicine-Saint Joseph University of Beirut, Beirut, Lebanon Department of Gynecology, Hôtel Dieu de France University Hospital, Faculty of Medicine-Saint Joseph University of Beirut, Beirut, Lebanon

^*Correspondance to: Nahed Damaj 

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Abstract:

Recurrent miscarriages can result from various causes, including thrombophilia. This study aims to determine the prevalence of thrombophilia among Lebanese women experiencing recurrent miscarriages. It includes 50 patients with a history of Recurrent Miscarriages (RM) who were suspected of having thrombophilia and underwent thrombotic risk assessment (CVD) between 2019 and 2023. Genetic testing using PCR-SSO was performed to identify mutations in factor V (Factor V Leiden and Factor V R2), prothrombin, factor XIII, fibrinogen, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and thrombotic genotypes of PAI, ACE, and ApoE. All 50 patients were found to carry at least one mutation potentially associated with miscarriage. Mutation frequencies were 64% for MTHFR C677T, 52% for fibrinogen, 44% for MTHFR A1298C, 22% for FV R2, 14% for FXIII V34L, 6% for FV Leiden, and 4% for prothrombin G20210A. Genotypic analysis revealed 82% with the ACE D allele, 72% with the PAI 4G allele, and 8% with the ApoE E4 allele. These findings suggest that mutations in MTHFR, prothrombin, FV Leiden, and elevated PAI levels may increase the risk of recurrent miscarriage, with MTHFR mutations, the ACE D allele, and the PAI 4G allele being the most frequent in the Lebanese population studied.

Keywords:

Thrombophilia; Miscarriages; Recurrent miscarriages; Genetic mutation; T hrombotic genotype

Cite the Article:

El Karak F, Chebly E, Damaj N, Adaime A, El Kassis N, Abi Tayeh G, et al. Prevalence of Thrombophilia in Lebanese Women with Recurrent Miscarriages. Clin Oncol. 2025; 10: 2124..