Microrna-4429 Negatively Affects Colorectal Cancer Cell Invasion and Migration via Regulating SMAD3-Induced Epithelial-Mesenchymal Transition

Zhe Zhang, Yongxi Wang, Zhuo Chen, Guozheng Xu, Tingting Zhao and Fang Wang

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, China Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, China

^*Correspondance to: Zhang Zhe 

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Abstract:

Colorectal Cancer (CRC) is one common carcinoma and the fourth primary cause of cancer-caused death, with dismal prognosis. Studies have reported that miR-4429 develops anti-cancer function in follicular thyroid carcinoma and non-small cell lung cancer. However, its regulation mechanism in CRC and whether miR-4429 is implicated in the regulation of pathological activities are not investigated. The aim of our study was to explore the potent role of miR-4429 in CRC. In the present study, miR-4429 was a low-expressed gene in CRC cells and gain-of-function experiments displayed that miR-4429 promotion inhibited cell proliferation, migration, invasion and EMT process. It was viewed from mechanism assays that miR-4429 targeted Forkhead box M1 (FOXM1) and therefore regulate SMAD family member 3 (SMAD3) expression. Rescue experiments exposed that miR 4429 influenced cell proliferation, migration, invasion and EMT process in CRC by modulation of FOXM1-activated SMAD3. Our study detected that miR-4429 targeted FOXM1 to decrease SMAD3 expression and impeded cell proliferation, migration and invasion and EMT process of CRC cells, offering better direction in respect of investigation of the mechanisms in CRC and promising therapeutic targets for CRC.

Keywords:

Colorectal cancer (CRC); miR-4429; FOXM1; SMAD3

Cite the Article:

Zhang Z, Wang Y, Chen Z, Xu G, Zhao T, Wang F. Microrna-4429 Negatively Affects Colorectal Cancer Cell Invasion and Migration via Regulating SMAD3-Induced Epithelial-Mesenchymal Transition. Clin Oncol. 2025; 10: 2122..