High Plasma Level of Vitamin B12 (Cobalamin [Cbl]) Associated with Early Breast Cancer (EBC) Diagnosis: A Case Report

Sharif Kullab, Ahmed Jamal, Yahya Al-Imamah and Frederique Penault-Llorca

Department of Oncology, King Saud University (KSU), Riyadh, Saudi Arabia Frederique Penault-Llorca Centre Jean Perrin (CJP), Clermont-Ferrand France, France

^*Correspondance to: Sharif Kullab 

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Abstract:

Measurement of plasma vitamin B12 or Cobalamin (Cbl) is requested frequently in routine blood tests. Incidental findings of elevated levels of plasma Cbl are not uncommon, but they remain underestimated. However, it can be associated with serious medical situations such as underlying non-malignant or malignant disease. Such association with non-malignant disease is widely described and understood. Nonetheless, its relationship with underlying cancer conditions is still not well defined and not completely clear. We report an incidental finding of persistent elevated plasma levels of Cbl. Investigation of this clinical situation leads to Breast Cancer (BC) diagnosis at an early stage. Treatment of this patient’s breast cancer was characterized by a progressive decrease and then normalization of her plasma Cbl level. Some retrospective and prospective studies support the relationship between BC and a high plasma level of Cbl. However, the mechanism of action and the real relation are still poorly understood and encompass several other risk factors, mainly genetic and nutritional factors.

Keywords:

Breast Cancer (BC); High/elevated plasma level of vitamin B12 (Cobalamin [Cbl]); Early Breast Cancer (EBC)

Cite the Article:

Sharif Kullab, Ahmed Jamal, Yahya Al-Imamah, Frederique Penault-Llorca. High Plasma Level of Vitamin B12 (Cobalamin [Cbl]) Associated with Early Breast Cancer (EBC) Diagnosis: A Case Report. Clin Oncol. 2024; 9: 2119..