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**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Thoracic Oncology
- Radiation Oncology
- Endoscopy Methods
- Radiation Therapy
- Central Nervous System Tumors
- Surgical Oncology
- Palliative Care
- Kidney Cancer
Abstract
Citation: Clin Oncol. 2024;9(1):2116.DOI: 10.25107/2474-1663-v9-id2116
SLC39A10 Expression is Associated with the Prognosis of Hepatocellular Carcinoma and the Tumor Immune Microenvironment
Li S and Liu S
The First Affiliated Hospital, Harbin Medical University, Harbin, China College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
*Correspondance to: Shichao Liua
PDF Full Text Research Article | Open Access
Abstract:
Zinc is essential for cellular processes and has been implicated in the development of various malignancies. The protein SLC39A10, which facilitates zinc transport, is suspected to contribute to tumor growth in multiple types of cancer. Our research delves into the function of SLC39A10 in Hepatocellular Carcinoma (HCC), particularly its impact on immune system reactions and its significance as a predictor of patient outcomes. By examining data from The Cancer Genome Atlas, GEO, and HPA, we observed that SLC39A10 levels were notably higher in HCC tissues compared to non-cancerous ones. This increase in SLC39A10 expression was associated with more severe stages and grades of cancer. Individuals with elevated SLC39A10 levels tended to have a less favorable prognosis in terms of overall survival. We mapped a protein interaction network involving SLC39A10 and explored its potential links to the presence of immune cells within tumors. his analysis was conducted using Gene Ontology, we employed Gene Set Enrichment Analysis (GSEA) and single-sample GSEA to delve into the relationship between SLC39A10 gene expression and immune cell infiltration. By leveraging databases like the Gene Expression profiling interactive analysis and the tumor immune estimation resource, we examined how SLC39A10 levels correspond with immune cell infiltration markers. The findings from our study suggest that SLC39A10 may play a pivotal role in the progression of Hepatocellular Carcinoma (HCC) and in the tumor's capacity to elude immune responses, highlighting its potential as a prognostic biomarker for patient outcomes. his revised version aims to provide a fresh perspective on the original text while preserving the scientific findings and conclusions.
Keywords:
SLC39A10; ZIP10; Hepatocellular carcinoma; Zinc ion transporter
Cite the Article:
Li S, Liu S. SLC39A10 Expression is Associated with the Prognosis of Hepatocellular Carcinoma and the Tumor Immune Microenvironment. Clin Oncol. 2024; 9: 2116..