^99mTc-PSMA in a Patient with Metastatic Castration- Resistant Prostate Cancer with False-Positive Post-Therapy ^99mTc-MDP Bone Scan

Alarcon S and Paredes E

Department of Nuclear Medicine, Clinica Ricardo Palma, Lima, Peru

^*Correspondance to: Shirley Marcela Alarcón Santisteban 

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Abstract:

Prostate cancer is the most frequent cancer diagnosis in men and the third cause of cancer-related death in men in Peru. The detection of lesions with overexpression of PSMA receptors in metastatic prostate cancer cells is detectable with PET/CT-PSMA, however due to its high cost and low availability in our country, we used the SPECT-CT study with ^99mTc-PSMA, which allows the localization of lesions with PSMA surface antigen expression, limiting the false positives that usually give conventional studies with SPECT-CT with ^99mTc-MDP. Bone scan usually present the flare phenomenon in those patients who have been irradiated and generate false positives in the control study, however with the use of ^99mTc-PSMA we reduce false positives by evidencing the avidity of PSMA active tumor cells that overexpress it, avoiding unnecessary treatment.

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Cite the Article:

Alarcon S, Paredes E. ^99mTc-PSMA in a Patient with Metastatic Castration- Resistant Prostate Cancer with False- Positive Post-Therapy ^99mTc-MDP Bone Scan. Clin Oncol. 2024;9:2093..