Extranodal Non-Hodgkins Lymphoma Involving Endometrium and Cervix – A Case Report

Sherry SA, Renu S, Siddharth S and Sreejith GN

Department of Medical Oncology, Regional Cancer Centre, India
Department of Pathology, Regional Cancer Centre, India

^*Correspondance to: Sreejith G Nair 

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Abstract:

Extranodal lymphomas involving the female genital tract is rare, ovary being the most common site followed by uterus, cervix, vulva and vagina. Patients usually present with non-specific symptoms like vaginal bleeding, persistent vaginal discharge, perineal discomfort or urinary obstruction due to the mass without typical “B symptoms” associated with lymphoma. Owing to the rarity and non-specific symptomatology, the diagnosis and treatment of these lymphomas are often delayed. Chemoimmunotherapy with Rituximab, Cyclophosphamide, Doxorubicin, Oncovin, and Prednisone (RCHOP) regime is the preferred treatment. A seventy-year-old lady presented with complaints of post-menopausal bleeding per vaginum and passage of clots and was subsequently diagnosed with high grade B cell Non-Hodgkins Lymphoma (NHL) of endometrium, Stage IV E. She attained complete response after 6 cycles of R CHOP and is on regular follow up now. This case is being reported in view of its rarity.

Keywords:

Extranodal lymphoma; Chemoimmunotherapy; High grade B cell lymphoma; Postmenopausal bleeding

Cite the Article:

Sherry SA, Renu S, Siddharth S, Sreejith GN. Extranodal Non-Hodgkins Lymphoma Involving Endometrium and Cervix – A Case Report. Clin Oncol. 2024;9:2087..