Tryptase and Chymase in Tumor - Associated Mast Cells in Prostate Cancer

Pavlov I, Pavlova T, Atiakshin D, Kostin A, Kaplin A, Buchwalow I and Tiemann M

Belgorod State National Research University, Belgorod, Russia
First Pavlov State Medical University of St. Petersburg, Russia
RUDN University, Moscow, Russia
Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, Russia
Kursk State Medical University, Kursk, Russia
Institute for Hematopathology, Hamburg, Germany

^*Correspondance to: Igor Buchwalow 

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Abstract:

Objective: Prostate cancer is one of the most common malignant diseases in men with a steady upward trend in the number of cases every year. Presently, special attention of researchers has been drawn to the search for new methods for diagnosing prostate cancer to provide more accurate diagnosis. In this work, we analyzed the expression of tryptase and chymase in tumor-associated Mast Cells (MC) in the prostate cancer. Methods: The detection of tryptase in the nuclei of tumor cells may indicate the realization of the anticarcinogenic effects of MC. At the same time, an increase in the number of macrophages with a pro-oncogenic CD68+/CD163+ phenotype in the tumor microenvironment indicates the possibility of the formation of a multidirectional action of immunocompetent cells in the prostate cancer. Results: We showed that the disease is accompanied by an increase in the MC population in the prostate gland and by an increase in the total pool of specific MC proteases in the tumor microenvironment. Conclusion: Thus, an increase in the expression of specific MC proteases in the tumor microenvironment of prostate cancer indicates the development of anticarcinogenic effects and may form personalized features of the immune landscape in the pathogenesis of the disease.

Keywords:

Prostate cancer; Mast cells; Immunohistochemistry; Tryptase; Chymase

Cite the Article:

Pavlov I, Pavlova T, Atiakshin D, Kostin A, Kaplin A, Buchwalow I, et al. Tryptase and Chymase in Tumor - Associated Mast Cells in Prostate Cancer. Clin Oncol. 2024;9:2047..