Serum Lipid Profile and Breast Carcinogenesis among Qatari Young Women

Al Ghatam G, El Mistiri M and Belbraouet S

Department of Health Science, CAS, Qatar University, Doha, Qatar
National Center for Cancer Care & Research, Qatar
School of Food Sciences, Nutrition and Family Studies, FSSSC, Université de Moncton, Canada

^*Correspondance to: Slimane Belbraouet 

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Abstract:

This study evaluates the possible association between serum lipids and the incidence of Breast Cancer (BC) in a control-case survey. The study conducted in Doha included 15 cases newly diagnosed with BC by National Center for Cancer Care & Research (NCCCR) and 30 controls (female students and staff enrolled in Qatar University); 21 to 55 years. 10 mL of whole blood was collected in EDTA tubes from subjects fasted at least 8 h. Serum was separated within 1 hour and then samples were stored at -80°C. Lipid profiles (serum TC, HDL, and TG) were analyzed using spectrophotometry. Serum LDL-Cholesterol was calculated using the Friedewald equation. The OR (and 95% CI) was used to ascertain the association between biochemical values and BC for patients and healthy controls, including serum TC, TG, HDL-C, and LDL-C. There are significantly lower values for serum HDL-C and higher for serum TC, LDL-C, and TG in patients compared to healthy controls (p<0.05). The OR and 95% CI using a binary logistic regression model are used to further explore the association between serum lipid parameters and the occurrence of BC. All the biochemical values showed significant differences between the BC patients and healthy controls. TC >5.18 mmol/L, LDL-C >3.36 mmol/L, TG >1.7 mmol/L, and HDL-C <1.00 mmol/L tend to be associated with BC. These findings, although analyzed on a limited number of individuals, seem to indicate an increase in serum lipid parameters and BC in premenopausal women.

Keywords:

Premenopausal breast cancer; Serum triglycerides; Serum total cholesterol; LDLcholesterol; HDL-cholesterol

Cite the Article:

Al Ghatam G, El Mistiri M, Belbraouet S. Serum Lipid Profile and Breast Carcinogenesis among Qatari Young Women. Clin Oncol. 2023;8:2025..