Immunohistochemical Detection of Prognostic Biomarkers in Canine Mammary Tumors and Relation with Malignancy and Prognosis

Kavisha G, Neeraj K, Avantika S, Motilal BA, Abhay BY, Suresh PC, Himani P, Prabhu SN, Renu S, Soumen C and Sanjay P

Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Veterinary University, India
Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Veterinary University, India
Department of Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Veterinary University, India

^*Correspondance to: Neeraj Kumar Gangwar 

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Abstract:

A definitive and early diagnosis is essential in neoplastic cases either in case of humans or animals for determining the line of treatment and better prognosis. The present study was conducted to record the prognostic biomarkers (Estrogen Receptor Alpha- (ERα), Progesterone Receptor- (PR), Human Epidermal growth factor Receptor 2- (HER-2) and Protein-53 (P-53) of different types of mammary gland tumors occurring in canines based on histopathological and immunohistochemical examination study of prognostic biomarkers (ERα, PR, HER-2 and P-53). Total 53 cases suspected for Canine Mammary Tumor (CMT) were encountered at Veterinary Clinical Complex, DUVASU, Mathura, India during the period from January 2021 to April 2022. Out of them 42 were neoplastic and 11 were non-neoplastic cases. The 2 cases out of total 42 neoplastic cases showed distant metastases in lungs. Out of 42 cases, total 24 tissue samples were obtained for further examination. Histopathological examination showed that more than one histopathological type of mammary tumor was present in one case, so total number of 32 tumors was found in 24 tissue samples. Most of the cases were malignant neoplasms with maximum occurrence of carcinoma solid (12.5%) and tubulo-papillary carcinoma (12.5%). Immunohistochemical examination showed that most of the malignant mammary neoplasm cases were negative for ERα, PR, HER-2 expressions i.e., triple negative and positive for P-53 immunohistochemistry expression 8/24 or 33.34% showed poor prognosis. The expression of biomarkers analysis and interpretation provides valuable diagnostic and prognostic significance regarding nature of tumor and start of treatment regimen in canine mammary tumors.

Keywords:

Canine Mammary Tumor; Biomarkers; Immunohistochemistry; Prognosis

Cite the Article:

Kavisha G, Neeraj K, Avantika S, Motilal BA, Abhay BY, Suresh PC, et al. Immunohistochemical Detection of Prognostic Biomarkers in Canine Mammary Tumors and Relation with Malignancy and Prognosis. Clin Oncol. 2023;8:1999..