Clin Oncol | Volume 8, Issue 1 | Research Article | Open Access
Ismaiel NA*, Rassul FE and Ahmad BJ
Department of Biology, Faculty of Science, University of Soran, Iraq
*Correspondance to: Narmeen Abdulsamad Ismaiel
Fulltext PDFBackground: An epigenetics paradigm and an effective model system for the generation of facultative heterochromatin throughout development are represented by the inactivation of the X chromosome. The expression of the XIST gene from the X chromosome that will be inactivated in females is the first step in the process of X Chromosomal Inactivation (XCI) (Xi). The idea of a direct role for BRCA1 in the localization of XIST was highlighted by the apparent cytological overlap between BRCA1 and XIST RNA across the Xi.
Objectives: The goal of the current study was to compare the prevalence of sex chromatin in breast and ovarian cancer patients with that of healthy, normal females.
Material and Methods: The blood smear samples from 30 healthy normal girls (25 with breast cancer and 25 with ovarian cancer) served as the study's main source of data. The modal occurrence rate of sex chromatin was determined by analyzing 100 polymorphonuclear neutrophils from each person.
Results: Our findings showed that there was a significant variation in the mean prevalence of sex chromatin among cancer patients.
Conclusion: This finding suggests that cancer patients' latent X chromosomes have been reactivated. With the help of this research, it may be possible to use the inactive X chromosome as an epigenetic biomarker in cancer at the molecular and cytological levels.
Sex Chromatin; Polymorphonuclear neutrophils; Breast cancer; Ovarian cancer
Ismaiel NA, Rassul FE, Ahmad BJ. Sex Chromatin Frequency Variation among Breast and Ovarian Cancer Patients. Clin Oncol. 2023;8:1981..