Clin Oncol | Volume 8, Issue 1 | Research Article | Open Access

The Use of Neutrophils-to-Lymphocytes and Platelets-to-Lymphocytes Ratios as a Prognostic Factor before and after Treatment of Epithelial Ovarian Cancer & Comparison with Clinical and Pathological Features

Zahav MH1, Shahar IB1,2, Zidan MD3, Safadi M4, Shnayder J4 and Zidan J1,4*

1Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel
2Department of Obstructive and Gynecology, Ziv Medical Center, Safed, Israel
3Women's Health Wing, The Galilee Medical Center, Naharya, Israel
4Division of Oncology, Ziv Medical Center, Safed, Israel

*Correspondance to: Jamal Zidan 

Fulltext PDF


Aims: The prognostic value of NLR (Neutrophils-to-Lymphocytes Ratio) and PLR (Platelets-to-Lymphocytes Ratio) in ovarian cancer is contradictory. The aim of this study was to assess the correlation between NLR and PLR with different characteristics of ovarian cancer.
Materials and Methods: This is a retrospective study. A total of 61 cases with ovarian cancer were summarized. Demographic, clinical, pathological data, blood counts, CA125 were taken from the patients' files. Values of NLR, PLR and CA125 were assessed prior to treatment and 1, 3, 6 months after beginning of treatment.
Results: Nine cases were excluded due to exclusion criteria while 52 pts were evaluable. The average age was 62 years. Most pts (76%) was stage III and IV at diagnosis. After 3 years follow up survival was 40% in pts with NLR<5.0 compared to 20% with NLR>5.0 (p=0.032), and 38% in PLR<250 vs. 19% in PLR>250 (p=0.007). CA125 levels were predicting factor in all stages of the disease. No relation was found between NLR, PLR, CA125 levels and disease features and ethnicity.
Conclusion: High rate of NLR and PLR in pts with ovarian cancer before and following treatment are negative prognostic factors. It is applicable in every medical center. No correlation was found between NLR and PLR with menopausal status, type of peration, age, chemotherapy and ethnicity. This study is the first to test NLR and PLR during and after treatment. The study is continued to
reach higher number of patients and more significant results.


Ovarian cancer; Neutrophils; Platelets to lymphocytes ratio


Zahav MH, Shahar IB, Zidan MD, Safadi M, Shnayder J, Zidan J. The Use of Neutrophils-to-Lymphocytes and Platelets-to-Lymphocytes Ratios as a Prognostic Factor before and after Treatment of Epithelial Ovarian Cancer & Comparison with Clinical
and Pathological Features. Clin Oncol. 2023;8:1980..

Subscribe to Our Newsletter