The Etiology of Gastrointestinal Bleeding with EBV - Associated Hemophagocytic Lymphohistiocytosis in Intestinal EBV-Positive Mucocutaneous Ulcer: A Rare Pathological Entity

Hua Pan, Shihong Shao, Maoqing Xing, Aiqin Song, Enben Guan, Liang Song, Xiaodan Liu and Yanxia Zhao

Department of Pediatric Intensive Care Unit, Affiliated Hospital of Qingdao University, China
Department of Pathology, Affiliated Hospital of Qingdao University, China
Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, China
Department of Hematology of Pediatrics, Affiliated Hospital of Qingdao University, China

^*Correspondance to: Yanxia Zhao 

 PDF  Full Text Case Report | Open Access

Abstract:

Epstein-Barr virus (EBV) positive Mucocutaneous Ulcers (EBVMCU) represent a newly recognized although uncommon disease, especially in children. Here we report an extremely rare case of a 17-month-old girl with intestinally localized EBVMCU EBV-associated hemophagocytic lymphohistiocytosis causing gastrointestinal bleeding without genetic abnormalities. Amongst
a range of tests used, pathological examination and immunochemistry proved mandatory for diagnosis. Thus, although rare, it is essential that physicians must be aware of this new disease for both accurate diagnosis and treatment.

Keywords:

EBV-positive mucocutaneous ulcer; Gastrointestinal bleeding; EBV-associated hemophagocytic lymphohistiocytosis

Cite the Article:

Pan H, Shao S, Xing M, Song A, Guan E, Song L, et al. The Etiology of Gastrointestinal Bleeding with EBV - Associated Hemophagocytic Lymphohistiocytosis in Intestinal EBV-Positive Mucocutaneous Ulcer: A Rare Pathological Entity. Clin Oncol. 2022;7:1947..