The Diagnosis Value of Soluble Programmed Death-Ligand 1 in Serum from Patients with Colorectal Cancer

Weifang Shao, Yanhua Xu, Suzhen Lin, Junli Gao, Junshun Gao and Hong Wang

Department of Medical Laboratory, Chang Xing People Hospital, China
Hangzhou Cosmos Wisdom Mass Spectrometry Center, Zhejiang University Medical School, China
These authors contributed equally to this work

^*Correspondance to: Suzhen Lin 

 PDF  Full Text Research Article | Open Access

Abstract:

Colorectal Cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the Programmed Death protein 1/Programmed Death Ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and diagnosis potential and clinicopathological features and prognosis of CRC patients. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient
sera compared to healthy donors (P<0.001). The median value of sPD-L1 in healthy donors, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78 ± 50.2 pg/mL, 284.12 ± 52.7 pg/mL and 321.31 ± 55.3 pg/mL respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC=0.861, 95% CI 0.830-0.887, p<0.001). sPD-L1 is a potential biomarker
for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P<0.01), and sPD-L1 was not correlated with the CRC prognosis (p>0.05).

Keywords:

Colorectal cancer; Soluble PD-L1 (sPD-L1); Lymph node metastasis; Diagnosis

Cite the Article:

Shao W, Xu Y, Lin S, Gao J, Gao J, Wang H. The Diagnosis Value of Soluble Programmed Death-Ligand 1 in Serum from Patients with Colorectal Cancer. Clin Oncol. 2022;7:1937..