Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Lung Cancers
  •  Kidney Cancer
  •  Prostate Cancer
  •  Blood Cancer
  •  Chemotherapy and Radiotherapy
  •  Colon Cancer
  •  Neoadjuvant Therapy
  •  Immunotherapy


Citation: Clin Oncol. 2022;7(1):1918.DOI: 10.25107/2474-1663.1918

Evolution of the Surgical Treatment of Mammary Paget’s Disease in Men: Updated Review of Case Reports from 2017 to 2021

Alberto Bouzón-Alejandro, Benigno Acea-Nebril, Ángela Iglesias-López, Alejandra García-Novoa, Carlota López-Domínguez, Carlota Czestokowa Díaz-Carballada and Carmen Conde Iglesias

Department of Surgery, University Hospital of A Coruña (CHUAC), Spain
Department of Radiology, University Hospital of A Coruña (CHUAC), Spain
Department of Gynecology, University Hospital of A Coruña (CHUAC), Spain

*Correspondance to: Alberto Bouz√≥n-Alejandro 

 PDF  Full Text Research Article | Open Access


Background: Mammary Paget's Disease (MPD) in men is extremely rare, with only 57 patients reported in the literature up to 2016, accounting for about 2% of all patients with MPD. Histopathological and immunohistochemical analyses are essential for diagnosis. Surgery is usually the first treatment that male patients with MPD receive.
Purpose: This review updates case reports published since 2017 and describes the evolution of the surgical treatment.
Methods: A systematic search for case reports of MPD in men published from 2017 to 2021 was performed.
Results: Twelve articles containing data of 14 male patients with MPD were included. The mean age was 63.6 years. Nine patients (64.3%) underwent mastectomy with Sentinel Lymph Node Biopsy (SLNB). The pathological examination of surgical specimens found an underlying Invasive Breast Carcinoma (IBC) in 7 cases (50%). Radical mastectomy and modified radical mastectomy were the predominant surgical procedures up to 2016.
Conclusion: The standard surgical treatment of MPD in male patients has changed from radical mastectomy to mastectomy with SLNB.


Mammary Paget’s disease; Breast carcinoma; Sentinel lymph node biopsy

Cite the Article:

Bouzón-Alejandro A, Acea-Nebril B, Iglesias-López Á, García-Novoa A, López-Domínguez C, Díaz-Carballada CC, et al. Evolution of the Surgical Treatment of Mammary Paget’s Disease in Men: Updated Review of Case Reports from 2017 to 2021. Clin Oncol. 2022;7:1918..

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