Anticancer Activity of Plant Derived Compounds: A Literature Based Review

Md. Mizanur Rahaman and Muhammad Torequl Islam

Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj-8100 (Dhaka), Bangladesh

^*Correspondance to: Md. Mizanur Rahaman 

 PDF  Full Text Review Article | Open Access

Abstract:

Since the dawn of time, plants have been employed as therapeutic agents. The high expense and severe side effects of conventional chemotherapy have lowered public acceptance and fueled the hunt for alternatives. Alternative therapy methods, such as phytochemicals, have become more widely available and cost-effective. Loss of mitochondrial membrane potential, release of cytochrome-c, and other processes and pathways are all involved in the anticancer activity of plantderived therapeutic substances. Anti-apoptotic proteins are down regulated, while pro-apoptotic proteins are up-regulated. Caspase, Fas, FADD, p53, and c-Jun signaling pathways are activated; Akt signaling pathway is inhibited; phosphorylation of ERK, P13K, Raf, survivin gene, STAT 3, and NF-kB is inhibited. In-vitro testing of skin cancer cell lines models allows researchers to discover the mechanisms of action of chemicals derived from plants against a variety of skin malignancies. As a result, the goal of this study is to provide an overview of plant-derived anti-cancer chemicals that have been found to have promising anti-carcinogenic activities.

Keywords:

Plant derived; Anti-carcinogenic; Cancer; Phytochemicals; Phytoconstituents

Cite the Article:

Rahaman M. M, Torequl Islam M. Anticancer Activity of Plant Derived Compounds: A Literature Based Review. Clin Oncol. 2022;7:1917..