Clin Oncol | Volume 7, Issue 1 | Review Article | Open Access

Pathological Features of Primary Thyroid Lymphoma

Midori Wakiya*, Hiroshi Hirano, Akira Okimura, Yumika Ito and Munehide Nakatsugawa

Department of Diagnostic Pathology, Hachioji Medical Center, Tokyo Medical University, Japan

*Correspondance to: Midori Wakiya 

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A primary thyroid lymphoma is a type of malignancy that originates in the thyroid gland. Most are either a Diffuse Large B-Cell Lymphoma (DLBCL) or Mucosa-Associated Lymphoid Tissue (MALT) lymphoma, while some cases develop from a MALT lymphoma. Since the histological features of a primary thyroid lymphoma including rare subtypes are the same as those of a malignant lymphoma arising from sites other than the thyroid, diagnosis is generally not difficult. In contrast, Hashimoto’s
thyroiditis occurs in the thyroid and more than half of primary thyroid lymphoma and MALT lymphoma cases are associated with that, making it sometimes difficult to distinguish differences for correct diagnosis. This article describes various pathological features of primary thyroid lymphoma including rare subtypes, with the aim of correct pathological diagnosis for affected patients.


Thyroid; Diffuse large B-cell lymphoma; Immunohistochemistry


Wakiya M, Hirano H, Okimura A, Ito Y, Nakatsugawa M. Pathological Features of Primary Thyroid Lymphoma. Clin Oncol. 2022;7:1907..

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