Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Palliative Care
  •  Gastrointestinal Cancer
  •  Breast Cancer
  •  Targeted Therapy
  •  Adjuvant Therapy
  •  Surgical Oncology
  •  Urological Cancers
  •  Stomach Cancer


Citation: Clin Oncol. 2021;6(1):1872.DOI: 10.25107/2474-1663.1872

Basal Cell Carcinoma Treated with HeberFERON. A Real World Retrospective Study

Martínez-Suárez C, Roben-Aguilar Y, Reyes-Acosta O, Garcia-Vega Y, Vega- Abascal J, Sánchez-Linares V, Sotolongo-Díaz D, Piña-Rodriguez Y, Fernández-Martori M, Betancourt-Pérez A, Jimenez-Lamas M, Ballester-Caballero Y, Pérez-Morgado R, Curbelo-Alonso M, Molina-Abad A, Martínez-Borrego R, Maturell-Peraza J, Pulido- Garcia L, López-Pupo N, Ramírez-Hidalgo Y, Ramos-Trujillo M, Fernández-Ramirez I, Hernández-Colina M, Perez –Lopez A, Leon-Garcia Y, Chaya-Salgado S, La O-Ayala Y, Hernández-Rodriguez R, Duncan-Roberts Y and Bello-Rivero I

Department of Clinical Investigations, Center for Genetic Engineering and Biotechnology (CIGB), Cuba
Production Direction, Center for Genetic Engineering and Biotechnology (CIGB), Cuba
Promotion and Distribution Direction, Center for Genetic Engineering and Biotechnology (CIGB), Cuba
Department of Clinical Trial, Center of Molecular Immunology (CIM), Havana, Cuba
Jose Avila Serrano Polyclinic, Holguin, Cuba
Center Polyclinic, Santi Spiritus, Cuba
Department of Dermatology, Antonio Luaces Iraola Hospital, Ciego de Avila, Cuba
Faustino Perez Hospital, Cuba
Carlos J. Finlay Polyclinic, Colon, Matanzas, Cuba
Arnaldo Milian Castro Hospital, Villa Clara, Cuba
Maria Curi Oncological Hospital, Cuba
Amalia Simoni Hospital, Camagüey, Cuba
Department of Maxillofacial Surgery, Antonio Luaces Iraola Hospital, Ciego de Avila, Cuba
Gustavo Aldereguia Hospital, Cienfuegos, Cuba
Pablo Noriega Polyclinic, Mayabeque, Cuba
Comandante Pinares Hospital, San Cristobal, Artemisa, Cuba
Heroes del Baire Hospital, Island of Youth, Cuba
Celia Sanchez Manduley Hospital, Manzanillo, Granma, Cuba
Juan Bruno Zayas Hospital, Santiago de Cuba, Cuba
Ernesto Guevara Hospital, Las Tunas, Cuba
Leon Cuervo Rubio Hospital, Pinar del Rio, Cuba
Agustinho Neto Hospital, Guantánamo, Cuba
Havana University, Cuba
Calixto Garcia Hospital, Cuba
Center of Medical Surgical Investigations (CIMEQ), Cuba
Salvador Allende Hospital, Cuba
Manuel Fajardo Hospital, Havana, Cuba

*Correspondance to: Iraldo Bello Rivero 

 PDF  Full Text Research Article | Open Access


Background: Basal cell carcinoma is the most common type of skin cancer with major impact in health-related quality of life. The use of the formulation based on the combination of IFN-alpha 2b and IFN-gamma (HeberFERON) is an effective alternative in the treatment of basal cell carcinoma, immunogenic tumor, potentially responsible to immunotherapies. The aim of this report is to record, retrospectively, the effect of HeberFERON patients with BCC in the Cuban real word condition.
Methods: This is a retrospectively study of the use of HeberFERON in real world conditions. Eligible patients were adults with histologic diagnosis of single or multiple basal cell carcinoma of any skin phototype, lesions of any size, subtype, location, recurrent or not, with or without specific prior treatments. Adult patients, who signed the informed consent to receive the treatment with HeberFERON, were identified from the data bases. The evaluation of clinical effectiveness was carried out according to RECIST 1.1. Ethical committee of participating institutions approved the study.
Results: In clinical practice evaluated patients the nose was the region of higher frequency of tumors (36.3%) and the nodular clinical subtype was the predominant (45.3%). Clinical response rate differences (p=0.000) were found, with complete response of 61.9%, and partial response of 32.7%; with an overall response rate of 94.2% The HeberFERON exerted a 100% disease control, with no progression reported in 640 treated patients. The best responder tumor subtypes to HeberFERON were the more aggressive tumors, morpheaform with complete response of 72% (overall response=96%), followed by the infiltrative with complete response of 66.7% (overall response =100%). Tumor with larger size and patients with more than four tumors had lesser response to the antitumor effect of HeberFERON.
Conclusion: HeberFERON was highly effective in basal cell carcinomas in real world conditions. In the context of resistance of skin tumors to hedgehog and immune check point inhibitors the combination of IFNs alpha 2b and IFN gamma appears as a plausible therapeutic option for a wide number of basal cell carcinomas.


Basal cell carcinoma; Multiple basal cell carcinomas; Interferon combination

Cite the Article:

Martínez-Suárez C, Roben-Aguilar Y, Reyes-Acosta O, Garcia-Vega Y, Vega- Abascal J, Sánchez-Linares V, et al. Basal Cell Carcinoma Treated with HeberFERON. A Real World Retrospective Study. Clin Oncol. 2021;6:1872..

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