Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Prostate Cancer
  •  Chemotherapy and Radiotherapy
  •  Targeted Therapy
  •  Hormone Therapy
  •  Breast Cancer
  •  Cervical Cancer
  •  Blood Cancer
  •  Head and Neck Oncology

Abstract

Citation: Clin Oncol. 2021;6(1):1837.DOI: 10.25107/2474-1663.1837

Acquired Factor XIII Deficiency in a Patient with Metastatic Lung Cancer

Ana Sofia Mendes, Marco Dias, Sara Morais, Raquel Romão, Bernardo Teixeira, Cláudia Pedrosa, Isa Peixoto, Paula Fidalgo and António Araújo

Department of Medical Oncology, Porto University Hospital Center, Portugal

*Correspondance to: Ana Sofia Mendes 

 PDF  Full Text Short Communication | Open Access

Abstract:

Introduction: Acquired Factor XIII (FXIII) deficiency can result in life-long bleeding tendency and can be caused by enhanced consumption, impaired synthesis, or as an immune-mediated process. The latter can be related with solid neoplasms, through neutralizing or non-neutralizing antibodies. The relationship between FXIII activity and Non-Small Cell Lung Cancer (NSCLC) is not well established. This case report is about a patient with NSCLC and acquired FXIII deficiency.
Materials and Methods: Clinical records were obtained through the electronic process analysis, and the confidentiality of the patient was always assured.
Results and Discussion: A 70-year-old male with no relevant past medical history and a recently diagnosed metastatic NSCLC was admitted for priapism. Five days later, a he developed a bleeding disorder, with slightly elevated coagulation times and normal fibrinogen levels and platelets count. FXIII level was found to be decreased (0.24 IU/mL) and FXIII plasma mixing studies did not
confirm the presence of a neutralizing inhibitor. The FXIII level correction with standard plasma mixing studies was in favor of a non-neutralizing antibody. Despite treatment, hemorrhage control was not achieved and the patient died.
Conclusion: This clinical report describes a rare case of a patient with metastatic NSCLC presenting a severe hemorrhagic event caused by FXIII deficiency immune-mediated by non-neutralizing antibodies and subsequent increased clearance.

Keywords:

Cite the Article:

Mendes AS, Dias M, Morais S, Romão R, Teixeira B, Pedrosa C, et al. Acquired Factor XIII Deficiency in a Patient with Metastatic Lung Cancer. Clin Oncol. 2021;6:1837..

Search Our Journal

Journal Indexed In

Articles in PubMed

NMR Metabolomics in Ionizing Radiation
 PubMed  PMC  PDF  Full Text
Metastatic Retroperitoneal Paraganglioma: Case Report and Review of the Literature
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Prevalence and Mortality of Skin Cancer in an Arsenic Exposed Population in District of Nadia, West Bengal, India
 Abstract  PDF  Full Text
The Expression and Relationship of Tc17 Cells and Interleukin-27 in Local and Systemic Environment of Nonsmall Cell Lung Cancer
 Abstract  PDF  Full Text
View More...