Eman Alshahmi1, Esra Obida2, Fatma Emaetig2, Fauzia Elgaraboli3 and Omar Alqawi4*
1Department of Zoology, Misurata University, Libya
2Department of Histopathology, National Cancer Institute, Libya
3Department of Genetics, Misurata University, Libya
4Biotechnology Research Centre-Misurata, National Cancer Institute, Libya
Background: The Bcl-2 oncoprotein inhibits programmed cell death or apoptosis. Over production of Bcl-2 protein occurs in a wide variety of human cancers including prostate cancer and presumably contributes to tumor expansion by prolonging cell survival through inhibition of apoptosis.
Objectives: This study aims to evaluate the Bcl-2 expression in benign prostatic hyperplasia and prostate cancer tissues. In addition, it focuses on finding the association of Bcl-2 protein expression in prostate malignant tissues with the clinical data of the patients such as age and tumor stage.
Materials and Methods: Tissue samples from 49 patients with prostate diseases included 40 adenocarcinoma and 9 benign prostate hyperplasia cases. The patients underwent curative surgical prostatectomy or prostate true cut biopsy at National Cancer Institute (NCI)-Misurata at the period from 2016 to 2018. Immunoreactivity for Bcl-2 expression was examined by immunohistochemistry method. The clinical and histopathological information included age and Gleason score was collected from the patients' files.
Results: Among the studied 40 cases of adenocarcinoma 22/40 (55%) showed positive immunostaining of Bcl-2 protein. The statistical analysis of the results revealed that there was no significant correlation between Bcl-2 expression level in benign and in cancer prostate tissues (p-value =0.485). In addition, no significant association between Bcl-2 expression and the age or the
tumor stage of patients.
Conclusion: Our data revealed that the predictive and prognostic role of Bcl-2 protein in prostate cancer was not noticed in this study.
Prostate cancer; Bcl-2 protein; Apoptosis; Immunohistochemistry
Alshahmi E, Obida E, Emaetig F, Elgaraboli F, Alqawi O. The Expression Profile of Bcl-2 Protein in Prostate Cancer Patients. Clin Oncol. 2021;6:1833..