Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Bladder Cancer
  •  Melanoma/Skin Cancer
  •  Kidney Cancer
  •  Colon Cancer
  •  Lymphoma
  •  Prostate Cancer
  •  Hematology
  •  Hormone Therapy


Citation: Clin Oncol. 2021;6(1):1830.DOI: 10.25107/2474-1663.1830

BCL2 Antagonist Venetoclax Combined with Non-Aggressive Chemotherapy in Treating Fatal TCF3-HLF Positive Acute  Lymphoblastic Leukemia

Wang P, He Y, Wang J, Ye Q, Zhang H and Zhang W

Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China

*Correspondance to: Weina Zhang 

 PDF  Full Text Case Series | Open Access


TCF3-HLF-fusion positive Acute Lymphoblastic Leukemia (ALL) is very rare and nearly incurable according to current standard chemotherapy even with hematopoietic stem cell transplantation. Optimized treatment strategies are urgently needed. In this report we present two cases with TCF3-HLF fusion with different therapeutic regimens and review ever reported cases in  literature. We proposed that combination of BCL2 antagonist venetoclax with non-aggressive chemotherapy should be considered for this fatal subtype ALL in the future.


TCF3-HLF; Acute lymphoblastic leukemia; BCL2 antagonist venetoclax; Nonaggressive chemotherapy

Cite the Article:

Wang P, He Y, Wang J, Ye Q, Zhang H, Zhang W. BCL2 Antagonist Venetoclax Combined with Non-Aggressive Chemotherapy in Treating Fatal TCF3-HLF Positive Acute Lymphoblastic Leukemia. Clin Oncol. 2021;6:1830..

Search Our Journal

Journal Indexed In

Articles in PubMed

LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma
 PubMed  PMC  PDF  Full Text
Metastatic Retroperitoneal Paraganglioma: Case Report and Review of the Literature
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Absolute dPCR Quantification of MicroRNAs by Absolute dPCR for the Diagnostic Screening of Colon Cancer
 PDF  Full Text
Immunohistochemistry Biomarkers in Bladder Cancer: The Old and the New Immunohistochemistry Markers in Bladder Cancer
 Abstract  PDF  Full Text
View More...