Clin Oncol | Volume 6, Issue 1 | Mini Review | Open Access

Proliferation and Survival Signals in Exosomes as Biomarkers for Colorectal Cancer

Ryan N Fuller, Paul A Vallejos and Nathan R Wall*

Department of Basic Sciences, Loma Linda University School of Medicine, USA

*Correspondance to: Nathan R Wall 

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Colorectal Carcinoma (CRC) is the second most common cancer as well as a major leader in cancer associated deaths worldwide. While early diagnosis correlates with a high 5-year survival rate, latestage CRC is often untreatable, leading to a less than 5-year survival in approximately 85% of cases. Our lab, and many others, believes that cancer-derived exosomes contain tumor factors important for diagnosing and prognosing CRC. Cancer-derived exosomes can be isolated from blood plasma
early in tumor development and can be used for frequent screening with rapid results. Of note, proliferative and survival signals found in exosomes are conserved across CRC, as well as many other tumor types, and can be used to easily discriminate from non-cancerous patient-derived exosomes. For this reason, we believe that exosomal proliferative and survival factors, in the form of proteins, genetic material and/or metabolites, are the key to developing biomarkers for this clinical achievement.


Proliferation; Survival; Exosomes; Biomarkers; Colorectal cancer


Fuller RN, Vallejos PA, Wall NR. Proliferation and Survival Signals in Exosomes as Biomarkers for Colorectal Cancer. Clin Oncol. 2021;6:1766..

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