Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Cervical Cancer
  •  Colorectal Cancer
  •  Gynecological Cancers
  •  Pancreatic Cancer
  •  Chemoprevention
  •  Immunotherapy
  •  Endoscopy Methods
  •  General Oncology


Citation: Clin Oncol. 2020;5(1):1738.DOI: 10.25107/2474-1663.1738

Towards Liver: Selected Aspects of Uveal Melanoma Metastasis

Martyna Elas, Małgorzata Szczygieł, Katarzyna Jasińska-Konior, Anna Kozińska, Anna Markiewicz and Bożena Romanowska-Dixon

Department of Biophysics, Jagiellonian University, Poland Department of Ophthalmology, Jagiellonian University Medical College, Poland

*Correspondance to: Martyna Elas 

 PDF  Full Text Review Article | Open Access


Background: Uveal Melanoma (UM) although a rare disease, causes high mortality due to metastases. Long-term prognosis may be estimated based on the genetic profile of the UM tumor, however, lack of effective and specific treatment prevents cure. Methods: This review summarizes current knowledge and outlines future directions relevant to UM metastatic disease. Results: The overall consensus is that UM micrometastases remain dormant for a number of years, before actively proliferating and becoming detectable clinically. The main site of UM metastases is the liver, constituting a very specific niche, and numerous molecular factors are involved in UM liver homing, like CXCL12-CXCR4. Conclusion: New avenues of research must include the mechanism of UM cells seeding from the primary tumor, homing to the liver, liver invasion, as well as UM cell dormancy.


Uveal melanoma; Metastasis; Liver niche; Dormancy

Cite the Article:

Elas M, Szczygieł M, Jasińska- Konior K, Kozińska A, Markiewicz A, Romanowska-Dixon B. Towards Liver: Selected Aspects of Uveal Melanoma Metastasis. Clin Oncol. 2020; 5: 1738.

Search Our Journal

Journal Indexed In

Articles in PubMed

Metastatic Retroperitoneal Paraganglioma: Case Report and Review of the Literature
 PubMed  PMC  PDF  Full Text
NMR Metabolomics in Ionizing Radiation
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Delivered Dose Verification for Lung Cancer Stereotactic Body Radiotherapy Using Cone-Beam CT
 Abstract  PDF  Full Text
Research Progress on the Origin and Mechanism of Liver Cancer Stem Cells
 Abstract  PDF  Full Text
View More...