Pleural Effusion in Blast Crisis Phase of Chronic Myeloid Leukemia: An Unusual Extramedullary Manifestation

Nova Ridha, Kevin Yonatan Budiman and Amaylia Oehadian

Department of Internal Medicine, Padjadjaran University, Indonesia

^*Correspondance to: Amaylia Oehadian 

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Abstract:

Pathogenesis of pleural effusion in Chronic Myeloid Leukemia (CML) is poorly understood and rarely reported in the literature. Extramedullary involvement has been reported in 10% of CML cases and mostly affects lymph nodes and spleen. Extensive pleural involvement of leukemia cells is rarely reported in CML. Here we report a 44-year-old Indonesian male having severe pleural effusion due to extramedullary manifestation of blast crisis CML. He had prior diagnosis of CML since August 2019, with positive Philadelphia (Ph) chromosome. Cytological examination of the pleural fluid revealed cells with the morphological features of myeloblasts. Initially the patient had a significant response to imatinib, but later he died because of poor adherence and disease progression.

Keywords:

Pleural effusion; Chronic myeloid leukemia; Philadelphia chromosome; Extramedullary blast crisis

Cite the Article:

Ridha N, Budiman KY, Oehadian A. Pleural Effusion in Blast Crisis Phase of Chronic Myeloid Leukemia: An Unusual Extramedullary Manifestation. Clin Oncol. 2020; 5: 1703.