Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Lung Cancers
- Pancreatic Cancer
- Brain and Spinal Cord Cancer
- Gynecological Cancers
- Thoracic Oncology
- Chemotherapy and Radiotherapy
- Surgical Oncology
- Colon Cancer
Abstract
Citation: Clin Oncol. 2020;5(1):1703.DOI: 10.25107/2474-1663-v5-id1703
Pleural Effusion in Blast Crisis Phase of Chronic Myeloid Leukemia: An Unusual Extramedullary Manifestation
Nova Ridha, Kevin Yonatan Budiman and Amaylia Oehadian
Department of Internal Medicine, Padjadjaran University, Indonesia
*Correspondance to: Amaylia Oehadian
PDF Full Text Case Report | Open Access
Abstract:
Pathogenesis of pleural effusion in Chronic Myeloid Leukemia (CML) is poorly understood and rarely reported in the literature. Extramedullary involvement has been reported in 10% of CML cases and mostly affects lymph nodes and spleen. Extensive pleural involvement of leukemia cells is rarely reported in CML. Here we report a 44-year-old Indonesian male having severe pleural effusion due to extramedullary manifestation of blast crisis CML. He had prior diagnosis of CML since August 2019, with positive Philadelphia (Ph) chromosome. Cytological examination of the pleural fluid revealed cells with the morphological features of myeloblasts. Initially the patient had a significant response to imatinib, but later he died because of poor adherence and disease progression.
Keywords:
Pleural effusion; Chronic myeloid leukemia; Philadelphia chromosome; Extramedullary blast crisis
Cite the Article:
Ridha N, Budiman KY, Oehadian A. Pleural Effusion in Blast Crisis Phase of Chronic Myeloid Leukemia: An Unusual Extramedullary Manifestation. Clin Oncol. 2020; 5: 1703.