Metastatic, Triple-Negative, Androgen Receptor-Positive, Invasive Lobular Carcinoma of the Breast: A Case Report

Kareen Ayre, Eva Olariu, Shi Wei, Drexel Boggs, Elizabeth Molony and Erica Stringer Reasor

Department of Surgery, Division of Surgical Oncology, University of Alabama at Birmingham, USA
Department of Medicine, Brookwood Baptist Health, USA
Department of Pathology, University of Alabama at Birmingham, USA
Department of Radiation Oncology, University of Alabama at Birmingham, USA
Department of Radiology, University of Alabama at Birmingham, USA
Department of Medicine, University of Alabama at Birmingham, USA

^*Correspondance to: Erica Stringer Reasor 

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Abstract:

Triple-Negative Breast Cancer (TNBC) is one of the most aggressive subtypes of breast cancer and tends to be of invasive ductal carcinoma histopathology. Less commonly found are Invasive Lobular Carcinomas (ILC) that are triple-negative. Various biological types of breast cancer have been identified through techniques, such as immunohistochemistry and gene profiling, which have helped to guide prognosis and treatment. To date, there have been no cases described as triplenegative (estrogen receptor negative, progesterone receptor-negative, and human epidermal  growth factor receptor-negative), Androgen Receptor (AR) positive, ILC that metastasized to the stomach, small bowel, bones, and dura mater. There are a few studies that report proximal small bowel metastasis in the setting of triple-negative, ILC; however, the AR status was not reported. We report a case of a 58 year-old Caucasian female diagnosed with de novo metastatic, triple-negative, AR-positive, ILC with multi-organ distant metastasis.

Keywords:

Triple-negative breast cancer; Invasive lobular carcinoma; Metastasis; Androgen receptor

Cite the Article:

Ayre K, Olariu E, Wei S, Boggs D, Molony E, Reasor ES. Metastatic, Triple-Negative, Androgen Receptor- Positive, Invasive Lobular Carcinoma of the Breast: A Case Report. Clin Oncol. 2019;4:1669.