A Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of Literature

Amina Mokrani, Fatma Guermazi, Asma Gargoura, Wafa Koubaa , Yosra Yahyaoui , Feryel Letaief , Azza Gabsi, Khedija Meddeb , Mouna Ayadi , Nesrine Chraiet , Henda Raies and Amel Mezlini

Department of Medical Oncology, Tunis El Manar University, TunisiaDepartment of Pathology, Tunis El Manar University, Tunisia

^*Correspondance to: Fatma Guermazi 

 PDF  Full Text Case Report | Open Access

Abstract:

Pure Large Neuro Endocrine Carcinoma (LCNEC) of the gallbladder is so rare that until now only 10 cases have been described. Herein we aimed to report a new case treated in the Salah Azaiez National Cancer Institute in Tunisia. We also reviewed the clinical features of all cases reported so far. We reported the case of 67 years old men that had pure locally advanced LCNEC of the gallbladder, with posterior metastatic lymphadenopathy. He underwent a cholecystectomy followed by 6 cycles of Cisplatin and Etoposide chemotherapy, 3 cycles of gemcitabine and Capecitabine chemotherapy and a third line of metronomic Cyclophosphamide.

Keywords:

Gallbladder; Neuroendocrine carcinoma; Large cells; CRP; CT

Cite the Article:

Mokrani A, Guermazi F, Gargoura A, Koubaa W, Yahyaoui Y, Letaief F, et al. A Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of Literature. Clin Oncol. 2019; 4: 1642 .