Restoring the Metabolic Syndrome-Cancer Hypothesis; Implications for Cancer Research and Treatment

Hammarsten J, Damber JE , Haghsheno MA , Mellström D and Peeker R

Department of Urology, University of Gothenburg, SwedenDepartment of Geriatrics, University of Gothenburg, Sweden

^*Correspondance to: Jan Hammarsten 

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Abstract:

The metabolic-cancer hypothesis was formulated in the 1990s and states that metabolic syndrome and its components are linked to cancer at all sites; however, the hypothesis collapsed in 2000s. A series of reports showed an inverse link between metabolic syndrome and its components and incident prostate cancer. Our research group recently showed that the inverse link between metabolic syndrome and its components and incident prostate cancer in the 2000s could be linked to bias mechanisms rather than prostate cancer biology. The findings restore the metabolic syndromecancer hypothesis and increase the interest in controlling lifestyle factors such as overconsumption of carbohydrates, chronic stress, smoking, vitamin D deficiency, and low physical activity as risk factors for cancer disorders. The data seem to suggest that by treating metabolic syndrome and its components, the risk of any cancer will decrease. The most robust data for achieving this goal come from reports of carbohydrate restriction

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Cite the Article:

Hammarsten J, Damber JE, Haghsheno MA, Mellström D, Peeker R. Restoring the Metabolic Syndrome-Cancer Hypothesis; Implications for Cancer Research and Treatment. Clin Oncol.2019;4:1636 .