Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  General Oncology
  •  Stomach Cancer
  •  Hormone Therapy
  •  Thoracic Oncology
  •  Radiation Therapy
  •  Lung Cancers
  •  Colon Cancer
  •  Head and Neck Oncology


Citation: Clin Oncol. 2019;4(1):1620.DOI: 10.25107/2474-1663.1620

CRMP-5 Positive Paraneoplastic Optic Neuropathy as Initial Presentation of Small Cell Lung Cancer

Dante M Sorrentino, Jennifer Lee and Gabrielle R Bonhomme

Department of Neuro-Ophthalmology, University of Pittsburgh Medical Center, USA

*Correspondance to: Gabrielle R Bonhomme 

 PDF  Full Text Research Article | Open Access


Paraneoplastic neurologic syndromes are manifestations of systemic malignancies. It is recognized as an immune mediated response that can rarely present as an optic neuropathy. Advancement in anti-neuronal antibody testing had led to increased identification of this paraneoplastic process. We describe a unique case of a 72-year-old male who presented with bilateral blurry vision and was found to have asymmetric optic disc edema on exam. His visual symptoms and exam findings were rigorously investigated with imaging, serology testing, lumbar puncture, ophthalmic ancillary testing, and biopsy. His chest and abdominal imaging were concerning for lung cancer. The suspicion of a metastatic neuroendocrine lung primary was confirmed by fine-needle aspiration biopsy. His serology and cerebrospinal fluid were positive for an anti-neuronal autoantibody known as Collapsin Response-Mediator Protein-5 (CRMP 5). He was subsequently diagnosed with Paraneoplastic Optic Neuropathy (PON) due to metastatic small cell lung carcinoma. Unlike other cases of PON, our patient’s vision loss prompted work-up for malignancy. Moreover, he did not demonstrate the typical findings associated with PON such as vitreous inflammation, brainstem dysfunction, or cerebellar dysfunction. With chemotherapy and corticosteroids, his vision recovered. This case demonstrates the importance of recognizing vision loss as a sign of PON, a rare manifestation of systemic malignancy.


Cite the Article:

Sorrentino DM, Lee J, Bonhomme GR. CRMP-5 Positive Paraneoplastic Optic Neuropathy as Initial Presentation of Small Cell Lung Cancer. Clin Oncol. 2019; 4: 1620.

Search Our Journal

Journal Indexed In

Articles in PubMed

Metastatic Retroperitoneal Paraganglioma: Case Report and Review of the Literature
 PubMed  PMC  PDF  Full Text
NMR Metabolomics in Ionizing Radiation
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Pregnancy Associated Breast Cancer Prognosis and Outcome, Qatar Experience
 Abstract  PDF  Full Text
Systematic Review and Meta-Analysis of PD-1 and CTLA-4 Bispecific Antibody in the Treatment of Gastric Cancer
 Abstract  PDF  Full Text
View More...