Primary Cutaneous Adnexal Carcinoma of the Axilla: A Diagnostic Dilemma and Review of Literature

Casswell G, Bhatt N and Challapalli A

Department of Oncology, University Hospital Bristol NHS Foundation Trust, UK
Department of Pathology, University Hospital Bristol NHS Foundation Trust, UK

^*Correspondance to: Amarnath Challapalli 

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Abstract:

Primary cutaneous adnexal carcinomas are rare and often difficult to diagnose. This is particularly challenging when occurring in the axilla as they histologically resemble breast carcinoma and this is the lymphatic region to which breast cancer most commonly spreads. Management of this cancer both in the curative and palliative setting remains uncertain due to the paucity of data.This clinical case highlights these challenges and demonstrates an unusual pattern of distant metastatic spread. This case and review of the available published data both demonstrate the possible aggressive nature of primary cutaneous adnexal carcinoma, highlights the histological prognostic factors which impact disease free and overall survival. We discuss the roles of prophylactic regional nodal clearance, adjuvant chemotherapy and radiotherapy. The best palliative treatment options in the metastatic setting are not known and we outline our experience and reflect on those within the published data.

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Cite the Article:

Casswell G, Bhatt N, Challapalli A. Primary Cutaneous Adnexal Carcinoma of the Axilla: A Diagnostic Dilemma and Review of Literature. Clin Oncol. 2019; 4: 1599.